Argireline
aka Acetyl Hexapeptide-8 · Acetyl Hexapeptide-3 · Ac-EEMQRR-NH2
Mechanism
Argireline is a synthetic, topically applied cosmetic hexapeptide (N-acetylated, C-terminal amide; Ac-EEMQRR-NH2) corresponding to the N-terminal fragment (residues 12–17) of the SNARE protein SNAP-25. It is marketed as an anti-wrinkle agent that competitively interferes with SNARE complex assembly, attenuating catecholamine and acetylcholine release and thereby reducing the muscle contractions that drive expression lines — a botulinum-toxin-like mechanism but far weaker. In the U.S. it is regulated as a cosmetic ingredient, not as an FDA-approved drug.
Studied uses
- topical anti-wrinkle / expression-line cosmetic serums
- eye creams and anti-aging moisturizers
- 'topical Botox alternative' marketing (cosmetic claims only)
Identification
| CAS number | 616204-22-9 |
|---|---|
| Molecular formula | C35H62N14O11S |
| Sequence | EEMQRR |
| Typical dose | Topical only; formulated in cosmetics at roughly 5–10% of the supplier's peptide solution (which is itself dilute), applied to the skin. Not dosed systemically. |
| Half-life | Not well characterized for topical use; peptide is subject to dermal peptidase degradation. |
Safety
Regulated by the FDA as a cosmetic ingredient (topical), not approved as a drug; cosmetic anti-aging efficacy claims rest on limited, mostly manufacturer-funded studies. Generally well tolerated topically, with occasional mild local irritation. Not intended for injection. Not a WADA-prohibited substance.
Vendors selling Argireline
No vendor listings on file yet.
Research
Objective The primary objective of this study was to investigate the biological activities of freeze-dried Ganoderma lucidum (Reishi) extract obtained from hazelnut pruning waste and to compare its antioxidant, tyrosinase inhibitory and cytotoxic properties with two widely used cosmetic actives-argireline peptide and α…
source →Skin aging involves complex mechanisms such as overactivation of neuromuscular signals and oxidative stress.
source →Introduction Skin aging manifests as wrinkles, reduced elasticity, and roughness due to intrinsic and extrinsic factors. Peptide-based therapies enhance collagen synthesis and extracellular matrix integrity.
source →Background Intradermal botulinum toxin injections have been shown to reduce sebaceous gland activity and improve skin texture in patients with oily and acne-prone skin. However, needle-based application is associated with discomfort and potential side effects.
source →Background Bakuchiol (BAK) and acetyl hexapeptide-8 have favorable biological activities and have promising applications in the cosmetic industry. However, the evaluation of the biological activity of both alone or in combination has not been reported.
source →Today's consumer perception and expectations of personal care have gone beyond merely cleansing, moisturizing, and makeup products, focusing more on the reduction or elimination of signs of aging.
source →One class of cosmetic compounds that have raised interest of many experts is peptides. The search for ingredients with good biocompatibility and bioactivity has led to the use of peptides in cosmetic products.
source →Background Acetyl hexapeptide-8, also known as Argireline, is a topical, short-acting, synthetic peptide that has recently gained popularity for its antiwrinkle effects. This agent has emerged as a more accessible alternative to botulinum neurotoxin.
source →Argireline (Ac-EEMQRR-NH 2 ), a well-known neurotransmitter peptide with a potency similar to botulinum neurotoxins, reveals a proven affinity toward Cu(II) ions.
source →Background Photoaging is a process of the architecture of normal skin damaged by ultraviolet radiation. Topical cosmeceuticals have been used to treat this condition. The authors aimed to understand the mechanism and level of evidence of different commonly used cosmeceuticals used to treat photodamaged skin.
source →Objective To analyze the effects of Argireline on skin surface wrinkles using the Visia ® camera system developed by Canfield Scientific Inc., U.S.A., for facial image capture. Method Nineteen female participants were recruited from a plastic surgery clinic.
source →Introduction We propose a new facial lifting protocol using polydioxanone (PDO) threads embedded in acetyl hexapeptide-8 (Argireline [Arg]). We assume that Arg reinforces the effects of PDO threads, as it is a mimetic of botulinum toxin.
source →This study will evaluate the efficacy of the DIME Beauty Luminosity Eye Serum in improving the appearance of skin in the periorbital eye area. This study will last for 60 days. The study will be conducted as a single-arm trial in which all participants will use the test products.
source →In the realm of cosmetics, skin care accounts for a significant share accounting for 35.3% of the global market, creating a $121 billion industry. While many of the products claim to have unique, natural formulations that boost skin care, many products contain chemicals that are potentially damaging to skin.
source →This is a randomized double-blinded study examining the effect of topical Acetyl Hexapeptide-8 AH8) for improving the cosmetic appearance and experience of oily skin.
source →Background: \- Blepharospasm is caused by excessive contraction of the muscles that close the eye. One treatment is botulinum neurotoxin (BoNT), which works by weakening those muscles. Like BoNT, acetyl hexapeptide-8 (AH-8) works to weaken the muscles, but is available as a skin cream.
source →Background: * Blepharospasm is caused by excessive contraction of the muscles that close the eye. It can be treated with injections of botulinum neurotoxin (BoNT), which works by weakening those muscles.
source →The purpose of this study is to determine whether La Jolie gel is effective in the treatment of periorbital wrinkles.
source →