Bronchogen
aka AEDL · Ala-Glu-Asp-Leu · T-33 · lung peptide bioregulator
Mechanism
Synthetic short-chain tetrapeptide bioregulator (Ala-Glu-Asp-Leu, AEDL) from the Khavinson family of tissue-specific peptides, developed by Vladimir Khavinson and colleagues at the St. Petersburg Institute of Bioregulation and Gerontology and designed from amino-acid analysis of bronchial-mucosa peptide extracts. It is proposed to act epigenetically, penetrating cells and binding DNA to modulate tissue-specific gene expression and protein synthesis in bronchial epithelium and lung tissue. Evidence is almost entirely preclinical and from Russian-language sources; no controlled human clinical trials meeting international standards have been published. It is not FDA-approved or FDA-evaluated and is sold as a grey-market research compound.
Studied uses
- respiratory/bronchial tissue research (research only)
- investigational respiratory-aging and lung-function studies (preclinical)
Identification
| Molecular formula | C18H30N4O9 |
|---|---|
| Sequence | AEDL |
| Typical dose | No validated human dose; vendor 'research' protocols commonly cite ~2-3 mg/day for 10-20 day courses (subcutaneous, unverified, research-only) |
| Half-life | Short circulating half-life (minutes); like other Khavinson bioregulators, biological effects are claimed to outlast plasma presence. Not formally characterized in humans. |
Safety
Not FDA-approved or evaluated; no rigorous human safety data exist. Sold for research use only; human use is off-label and unvalidated. Not currently a WADA-listed substance.
Vendors selling Bronchogen
| Vendor | Size | Price | Listed purity | Trust |
|---|---|---|---|---|
| BioLongevity Labs | 20 mg | $69.97 | — | 96 |
| Ion Peptide | 20 mg | $79.00 | — | 95 |
Research
Ultrashort peptides (USPs), consisting of 2-7 amino-acid residues, are a group of signaling molecules that regulate gene expression and protein synthesis under normal conditions in various diseases and ageing. USPs serve as a basis for the development of drugs with a targeted mechanism of action.
source →There is a vast practice of using antimalarial drugs, RAS inhibitors, serine protease inhibitors, inhibitors of the RNA-dependent RNA polymerase of the virus and immunosuppressants for the treatment of the severe form of COVID-19, which often occurs in patients with chronic diseases and older persons.
source →It was shown that AEDG peptide (Ala-Glu-Asp-Gly, Epitalon) regulates the function of the pineal gland, the retina, and the brain. AEDG peptide increases longevity in animals and decreases experimental cancerogenesis.
source →Exogenous short biologically active peptides epitalon (Ala-Glu-Asp-Gly), bronchogen (Ala-Glu-Asp-Leu), and vilon (Lys-Glu) at concentrations 10 -7 -10 -9 M significantly influence growth, development, and differentiation of tobacco (Nicotiana tabacum) callus cultures.
source →The effect of the tetrapeptide bronchogen on the structural and functional state of the bronchial epithelium and inflammatory activity in the lungs was studied in the chronic obstructive pulmonary disease (COPD) model, created in rats by a 60-day intermittent exposure to nitrogen dioxide.
source →On the model of chronic obstructive pulmonary disease, the effect of therapy with low-molecular-weight peptides on restructuring and functional activity of bronchial epithelium for restoring the immune and barrier function of the lungs and prevention of inflammatory process progression was studied.
source →We verified expression of CXCL12 and Hoxa3 transcription factors of differentiation in cultures of human embryonic pancreatic and bronchial cells and CXCL12 and WEGC1 factors in a culture of human prostatic fibroblasts. Reduced expression of these differentiation markers was detected in late-passage (aging) cultures.
source →Thermodynamic parameters of DNA melting in the presence of a peptide bronchogen in various concentrations were estimated on a differential scanning microcalorimeter. Bronchogen was shown to serve as a DNA-stabilizing agent.
source →Marked fluorescence in cytoplasm, nucleus, and nucleolus was observed in HeLa cells after incubation with each of several fluorescein isothiocyanate-labeled peptides (epithalon, Ala-Glu-Asp-Gly; pinealon, Glu-Asp-Arg; testagen, Lys-Glu-Asp-Gly).
source →Case report Two young men were operated in our department for bronchiogen cysts with unusual locations. In the first case a mediastinal cyst caused severe swallowing problems, while in the second a retroperitoneal cyst resembled to an adrenal adenoma.
source →The purpose of the research study is to develop a new, more sensitive, and less invasive test for diagnosing lung cancer at an earlier stage, when it can more easily be cured.
source →The synthetic peptides--cardiogen, bronchogen, prostamax and pancragen were used to investigate their effect on organotypic tissue culture of explants from heart, lungs, prostatic gland and pancreas of young (3-week old) and aged (18-month old) rats.
source →The retroperitoneal bronchogenic cyst is an extremely rare anomaly. During the examination of an 18-year-old female patient due to her extreme thinness, the abdominal ultrasound and later the CT indicated as an accidental finding--a left side adrenal/suprarenal adenoma, which turned out to be hormonally inactive.
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