peptide wiki

Mechanism

Pre-mixed blend marketed as a skin and anti-inflammatory "beauty" combination. GHK-Cu is the copper-binding tripeptide glycyl-L-histidyl-L-lysine complexed with copper(II); it is widely used in topical cosmetics and studied for collagen synthesis, wound healing, and antioxidant signaling. KPV is the C-terminal tripeptide (Lys-Pro-Val) of alpha-MSH and acts as an anti-inflammatory primarily via NF-kB inhibition, without melanocortin-receptor activation. GHK-Cu appears in approved cosmetic products topically, but neither component is FDA-approved as an injectable therapeutic, and there is no controlled human efficacy or safety data for this specific blend — the rationale is inferred from the individual research/cosmetic compounds.

Studied uses

• skin health, collagen support, and cosmetic anti-aging (research only)
• anti-inflammatory and recovery support (research only)
• wound and tissue repair (research only)

Identification

Typical dose	Vendor-dependent; GHK-Cu commonly used topically in cosmetics, or 1-2 mg/day subcutaneous in research contexts; KPV 200-500 mcg/day. No validated combination dosing exists.
Half-life	GHK-Cu: short systemic half-life (minutes), with longer local tissue activity; KPV: short and not well characterized in humans

Safety

GHK-Cu is generally recognized as safe in topical cosmetic use, but injectable use of this blend is not FDA-approved and is sold as a research-only / grey-market product. No combination-specific human safety data. Excess parenteral copper exposure is a theoretical concern. Not evaluated by WADA as a blend.