Matrixyl
aka Palmitoyl Pentapeptide-4 · Palmitoyl Pentapeptide-3 · Pal-KTTKS · Palmitoyl-Lys-Thr-Thr-Lys-Ser
Mechanism
Matrixyl is the trade name for palmitoyl pentapeptide-4 (Pal-KTTKS), a topically applied cosmetic peptide consisting of the matrikine pentapeptide KTTKS — a subfragment of type I procollagen — conjugated to palmitic acid to improve skin penetration. It is marketed to stimulate fibroblast production of collagen, elastin, and other extracellular-matrix components, thereby reducing the appearance of fine lines and wrinkles. In the U.S. it is regulated as a cosmetic ingredient and is NOT an FDA-approved drug.
Studied uses
- topical anti-aging / wrinkle-reducing cosmetic serums and creams
- collagen-stimulating skincare formulations
- often combined with Matrixyl 3000 (with palmitoyl tripeptide-1) in cosmetics
Identification
| CAS number | 214047-00-4 |
|---|---|
| Molecular formula | C39H75N7O10 |
| Sequence | KTTKS |
| Typical dose | Topical only; commonly formulated in cosmetics around 3–8% of the supplier's diluted peptide solution. Not dosed systemically. |
| Half-life | Not well characterized for topical use; subject to dermal peptidase degradation. |
Safety
Regulated by the FDA as a cosmetic ingredient (topical), not approved as a drug; anti-aging efficacy evidence is limited and largely supplier-derived. Generally well tolerated topically. Not intended for injection. Not a WADA-prohibited substance.
Vendors selling Matrixyl
| Vendor | Size | Price | Listed purity | Trust |
|---|---|---|---|---|
| Ion Peptide | 10 mg | $129.00 | — | 95 |
Research
Therapeutic peptides are short chains of amino acids used to treat metabolic and endocrine conditions such as obesity and type 2 diabetes.
source →The self-assembly in aqueous solutions, cytocompatibility, and collagen production of lipopeptide C 16 -KTTKS and a variant with arginine substitution for lysine, C 16 -RTTRS, are investigated. C 16 -KTTKS is known commercially as Matrixyl and is used in cosmetic formulations as it can stimulate collagen production.
source →Introduction Skin aging manifests as wrinkles, reduced elasticity, and roughness due to intrinsic and extrinsic factors. Peptide-based therapies enhance collagen synthesis and extracellular matrix integrity.
source →Skin aging reflects both intrinsic biological decline and extrinsic influences collectively known as the skin exposome, including ultraviolet (UV) radiation, air pollution, psychosocial stress, fatigue, sleep disruption, and suboptimal lifestyle behaviors.
source →Facial aging is a multifactorial process involving changes in bone, fat compartments, ligaments, muscles, and skin. Collagen biostimulators, including synthetic agents and autologous platelet concentrates, have gained attention for facial rejuvenation.
source →Skin pigmentation disorders involve complex biological regulation, with tyrosinase (TYR) and melanocortin 1 receptor (MC1R) serving as key therapeutic targets.
source →Background With the rise of regenerative medicine and geroscience, translational research has shifted focus from lifespan to healthspan-years lived in good health.
source →Calcium hydroxylapatite (CaHA) is widely used in aesthetics for its dual role as a dermal filler and biostimulator, promoting collagen and elastin synthesis.
source →One class of cosmetic compounds that have raised interest of many experts is peptides. The search for ingredients with good biocompatibility and bioactivity has led to the use of peptides in cosmetic products.
source →Melanogenesis is a biochemical process that regulates skin pigmentation, which is crucial role in protecting against ultraviolet radiation. It is also associated with hyperpigmentation conditions such as melasma and age spots, which negatively impact aesthetics and self-confidence.
source →Wound healing is one of the most complex biological processes. Studies show that Matrixyl (MTI), known as a cosmetic peptide, can lead to a faster healing process. The contribution of MTI to collagen formation during wound healing also depends on its mode of delivery and its release over time.
source →Following our previous reports on dual-action antibacterial and collagenesis-inducing hybrid peptide constructs based on "pentapeptide-4" (PP4, with amino acid sequence KTTKS), whose N -palmitoyl derivative is the well-known cosmeceutical ingredient Matrixyl, herein we disclose novel ionic liquid/PP4 conjugates (IL-KTT…
source →