peptide wiki

Semax + Selank

aka Semax/Selank

Nootropic / Cognitive

Mechanism

Pre-mixed blend of Semax (an ACTH(4-10) analog) and Selank (a heptapeptide tuftsin analog), both developed at the Russian Institute of Molecular Genetics. The individual compounds are registered as prescription drugs in Russia (intranasal); neither is FDA- or EMA-approved. The blend itself is NOT clinically validated — no controlled trial has tested Semax and Selank co-administered.

Identification

Typical doseSemax 200–600 mcg + Selank 250–500 mcg intranasally per session, typically 1–2x/day; often combined in equal-ratio nasal spray formulations
Half-lifeSemax plasma ~2–5 min; Selank plasma ~2–10 min; CNS/functional effects of both extend several hours beyond clearance

Vendors selling Semax + Selank

VendorSizePriceListed purityTrust
Ion Peptide $59.00 95
Strate Labs 10 mg $64.95

Research

Therapeutic Peptides in Aesthetic, Metabolic and Endocrine Conditions: Effects, Safety, Clinical Applications, and Future Perspectives
Renke G, Chinellato L. · International journal of molecular sciences (2026) · review

Therapeutic peptides are short chains of amino acids used to treat metabolic and endocrine conditions such as obesity and type 2 diabetes.

source →
Abstracts from the 54<sup>th</sup> European Society of Human Genetics (ESHG) Conference: e-Posters
· European journal of human genetics : EJHG (2022) ·
source →
Studying the Toxic Effects of Some Biologically Active Peptides on the Model of Mouse Embryonic Stem Cells
Kobylyanskii AG, Zolotarev YA, Andreeva LA, Grivennikov IA, Myasoedov NF. · Bulletin of experimental biology and medicine (2017) · animal

We studied the effects of peptide drugs (HLDF-6, PGP, RPGP, and PGLP) and peptide pharmaceutical products (Semax, Selank, and thyroliberin) on proliferation and survival of mouse embryonic stem cells and their derivatives. Differentiation of mouse embryonic stem cells into neuronal precursors was evaluated.

source →
Natural and hybrid ("chimeric") stable regulatory glyproline peptides
Ashmarin IP, Samonina GE, Lyapina LA, Kamenskii AA, Levitskaya NG, Grivennikov IA, Dolotov OV, Andreeva LA, Myasoedov NF. · Pathophysiology : the official journal of the International Society for Pathophysiology (2005) · animal

The present concept of relative instability of regulatory peptides (RPs) in organisms must be amended. The recently characterized family of glyprolines and some other prolyl-glycyl-proline (PGP)-containing oligopeptides show the stability quite comparable with those of major pharmacological preparations.

source →