Syn-Ake
aka Dipeptide Diaminobutyroyl Benzylamide Diacetate · SYN-AKE · beta-Ala-Pro-Dab-NHBn diacetate
Mechanism
Synthetic cosmetic dipeptide (beta-alanyl-prolyl-diaminobutyroyl benzylamide, supplied as the diacetate salt) developed by Pentapharm/DSM to mimic Waglerin-1, a component of temple viper (Tropidolaemus wagleri) venom. It acts as a reversible antagonist of the muscle-type (m) nicotinic acetylcholine receptor, reducing repeated muscle contraction to soften expression wrinkles in a topical, Botox-mimetic fashion. It is a topical cosmetic ingredient, not a therapeutic drug, and has no FDA drug approval; cosmetic anti-wrinkle claims rest mainly on manufacturer studies. The diacetate salt molecular formula is C23H37N5O7 (active dipeptide core C19H29N5O3).
Studied uses
- topical anti-wrinkle / anti-aging skincare (expression-line softening)
- cosmetic 'Botox-alternative' serums and creams
Identification
| CAS number | 823202-99-9 |
|---|---|
| Molecular formula | C23H37N5O7 |
| Typical dose | Topical only; formulated at ~1-4% of a 0.05% peptide trade solution in finished cosmetics (no systemic/injectable dosing) |
| Half-life | Not characterized for systemic exposure; used topically as a cosmetic, not administered systemically |
Safety
Topical cosmetic ingredient, not an FDA-approved drug; efficacy evidence is largely manufacturer-derived. Generally regarded as well tolerated topically, but not evaluated for systemic or injectable use, which is unsafe and outside its intended use. Not a WADA-listed substance.
Vendors selling Syn-Ake
| Vendor | Size | Price | Listed purity | Trust |
|---|---|---|---|---|
| Ion Peptide | — | $129.00 | — | 95 |
| Verified Peptides | 200 mg | $85.00 | — | 86 |
Research
Biomimetic peptides represent a growing class of active ingredients in modern cosmeceuticals, designed to mimic the function of the naturally occurring peptides involved in skin homeostasis, repair, and regeneration.
source →Objectives Skin aging, influenced by intrinsic and extrinsic factors, includes photoaging caused by UV radiation, leading to ROS production and skin damage.
source →Calcium hydroxylapatite (CaHA) is widely used in aesthetics for its dual role as a dermal filler and biostimulator, promoting collagen and elastin synthesis.
source →Today's consumer perception and expectations of personal care have gone beyond merely cleansing, moisturizing, and makeup products, focusing more on the reduction or elimination of signs of aging.
source →One class of cosmetic compounds that have raised interest of many experts is peptides. The search for ingredients with good biocompatibility and bioactivity has led to the use of peptides in cosmetic products.
source →The increase in the aging population worldwide has led scientists to turn to research to prevent the aging process. In this context, synthetic peptides emerge as candidate molecules for developing new anti-aging products.
source →Antioxidant peptides are a class of biologically active peptides with low molecular weights and stable antioxidant properties that are isolated from proteins.
source →The targeted delivery of a hydrophilic Tripeptide-3 to the skin using microemulsions or nanoemulsions for facial oil reduction was the focus of this study.
source →Among the many aspects that contribute to the wellness of each individual, healthy and younger-looking skin play a relevant role, as clearly shown by the important growth of the skin-care products market observed in recent years.
source →Microneedling (MN) is a novel therapeutic modality in dermatology. Through physical trauma from needle penetration, MN induces a wound healing cascade with minimal damage to the epidermis. This allows for enhancement in the absorption of mainstay topical therapies across the thick stratum corneum.
source →Periorbital melanosis (under eye dark circles) is an often idiopathic cosmetically disturbing condition that is poorly responsive to currently available treatment modalities.
source →A skin anti-aging composition comprises: (i) a skin cellular synthesis booster (ii) a skin cellular energizer (iii) a skin cellular cleanser and (iv) a cosmetically-acceptable excipient.
source →