Thymosin Alpha-1 + Thymulin
aka Ta1 + Thymulin blend · Thymic peptide immune blend
Mechanism
Pre-mixed blend of two thymus-derived immune-modulating peptides. Thymosin Alpha-1 is a 28-amino-acid peptide that activates Toll-like-receptor signaling and promotes T-cell maturation and a Th1-skewed immune response; it is marketed abroad as Zadaxin and approved in numerous countries but is not FDA-approved in the United States. Thymulin is a 9-amino-acid, zinc-dependent thymic peptide that supports upstream T-cell maturation and helps balance cytokine output, partly via NF-kB modulation. There is no controlled human efficacy or safety data for this specific combination; the blend is sold as a research-only / grey-market product and the rationale is inferred from the individual peptides.
Studied uses
- immune support and modulation (research only)
- T-cell function and recovery from immune suppression (research only)
- general immune resilience stacking (research only)
Identification
| Typical dose | Vendor-dependent; component norms: Thymosin Alpha-1 ~1.6 mg subcutaneous 2x/week (Zadaxin reference); Thymulin variable in research contexts. No validated combination dosing exists. |
|---|---|
| Half-life | Thymosin Alpha-1: ~2 hours; Thymulin: short, not well characterized in humans |
Safety
Not FDA-approved in the US; sold as a research-only / grey-market blend. Thymosin Alpha-1 is approved as a drug (Zadaxin) in other countries but not as this combination. Thymulin's activity depends on adequate zinc status. No combination-specific human safety data. Not evaluated by WADA as a blend.
Vendors selling Thymosin Alpha-1 + Thymulin
| Vendor | Size | Price | Listed purity | Trust |
|---|---|---|---|---|
| Peptidology | 10 mg | $99.00 | — | 89 |
Research
Thymus endocrinology is characterized by the action of various hormones on the thymus endocrine milieu consisting of thymocytes, thymic epithelial cells and thymic stromal cells.
source →The thymus produces several putative thymic hormones: thymosin alpha 1, thymulin, and thymopoietin, which have been reported to circulate and to act on both prothymocytes and mature T cells in the periphery, thus maintaining their commitment to the T cell system.
source →The manuscript will provide an in-depth and critical review of the nomenclature, biochemistry, biological properties, and a summary of published and on-going clinical trials with all reported thymic preparations, including both partially purified thymic factors (e.g., thymosin fraction 5, thymostimulin) as well as puri…
source →