Dihexa
aka PNB-0408
Mechanism
Dihexa (PNB-0408) is a small-molecule hexapeptide-like analog of angiotensin IV developed at Washington State University by the Harding/Wright group as a preclinical candidate for Alzheimer's disease and cognitive decline. It is NOT FDA-approved and has never been tested in human clinical trials. The often-quoted claim that it is 'roughly ten million times more potent than BDNF' refers to EC50 comparisons in an in vitro dendritic spine assay, not clinical efficacy.
Identification
| CAS number | 1401708-83-5 |
|---|---|
| Molecular formula | C27H44N4O5 |
| Typical dose | 2-5 mg/day subcutaneous or 10-40 mg/day oral/intranasal; typical research cycles 4-6 weeks on with 2-4 weeks off |
| Half-life | 12.68 days (i.v., rat); 8.83 days (i.p., rat); ~2-4 hours estimated for oral/intranasal routes |
Vendors selling Dihexa
| Vendor | Size | Price | Listed purity | Trust |
|---|---|---|---|---|
| Moglabs | 5 mg | $40.00 | — | 96 |
| Licensed Peptides | 10 mg | $129.99 | — | 95 |
| Peptide Tech | — | $64.99 | — | 94 |
| Skye Peptides | 8 mg | $119.00 | — | 90 |
| Peptidology | 10 mg | $69.99 | — | 89 |
| Simple Peptide | — | $109.00 | — | 85 |
| Crystal Peptides | — | $114.00 | — | 66 |
| Certified Peptides | 5 mg | $165.00 | — | 62 |
| Certified Peptides | 50 mg | $240.00 | — | 62 |
| Ruo Bio | 5 mg | $38.00 | — | — |
| AMC Essentials | 5 mg | $39.99 | — | — |
| Flawless Compounds | — | — | — | — |
| Genetic Peptide | 5 mg | $100.00 | — | — |
| Genetic Peptide | 10 mg | $100.00 | — | — |
| Genetic Peptide | — | $200.00 | — | — |
| Kimera Chems | — | $121.99 | — | — |
| Nextech Labs | 4 mg | $90.00 | — | — |
| Paramount Peptides | 8 mg | $93.50 | — | — |
| Paramount Peptides | 30 mg | $175.00 | — | — |
| Paramount Peptides | 10 mg | $349.00 | — | — |
| Paramount Peptides | 10 mg | $110.00 | — | — |
Research
Therapeutic peptides are emerging as promising adjuncts in the management of orthopaedic injuries, grounded in their ability to modulate molecular signaling networks central to cellular medicine.
source →BACKGROUND: Pyroptosis plays an essential role in the pathological process of cerebral ischemia/reperfusion (I/R) injury. Hepatocyte growth factor (HGF)-modified stem cells improve brain I/R damage.
source →The growth factor and small molecule protocol are the two primary approaches for generating human induced pluripotent stem cell-derived hepatocyte-like cells (iPSC-HLCs). We compared the efficacy of the growth factor and small molecule protocols across fifteen different human iPSC lines.
source →Organoids have emerged as a powerful tool for modeling liver diseases, drug screening, and personalized treatments. However, they have a limited capacity to generate functional hepatocytes in a reproducible and efficient manner.
source →In recent years, an increasing number of case reports have mentioned the presence of illicit nootropics, smart drugs or mind doping products on the market.
source →Background Huntington's disease (HD) is a neurodegenerative disorder characterized by motor, cognitive, and psychiatric dysfunction caused by a mutant huntingtin protein.
source →The melon fruit fly, Bactrocera zonata (Coquillett) (Diptera: Tephritidae), is a notorious pest, posing a significant threat to a wide range of fruits and vegetables, leading to substantial agricultural losses worldwide.
source →Hepatocyte transplantation (HTx) has been a novel cell-based therapy for severe liver diseases, as the donor livers for orthotopic liver transplantation are of great shortage. However, HTx has been confronted with two main hurdles: limited high-quality hepatocyte sources and low cell engraftment and repopulation rate.
source →Background Various methods have been developed to generate hepatic cells from human pluripotent stem cells (hPSCs) that rely on the combined use of multiple expensive growth factors, limiting industrial-scale production and widespread applications.
source →Directed differentiation of human induced pluripotent stem cells (iPSCs) into hepatocytes could provide an unlimited source of liver cells, and therefore holds great promise for regenerative medicine, disease modeling, drug screening and toxicology studies.
source →The renin-angiotensin system (RAS) is a paracrine RAS within the central nervous system (CNS) and is closely related to Alzheimer's disease (AD). The endogenous hexapeptide angiotensin IV (Ang IV), an important component of the brain RAS, was found to rescue cognitive impairment and recover memory in previous studies.
source →Background Optimizing nerve regeneration and re-innervation of target muscle/s is the key for improved functional recovery following peripheral nerve damage.
source →