peptide wiki

Prostamax

aka prostamaxum

Immune Modulator

Mechanism

Prostamax is a Khavinson-series 'peptide bioregulator' associated with the synthetic tetrapeptide Lys-Glu-Asp-Pro (KEDP), positioned as a short-peptide analog of bovine prostate extracts (in the same Russian product family as Prostatilen / Vitaprost). It is marketed on the Russian/Ukrainian grey market as a dietary peptide for prostate support; not an FDA-approved drug and not a substitute for evaluated BPH or prostatitis therapies. Research-use only in the US.

Identification

CAS number473578-47-1
Molecular formulaC20H33N5O9
SequenceKEDP
Typical dose100–1000 mcg/day (research use; commonly 500 mcg–1 mg/day IM or oral capsule, cyclically 10–20 days per cycle)

Vendors selling Prostamax

VendorSizePriceListed purityTrust
BioLongevity Labs 20 mg $79.97 96
Peptide Tech 20 mg $39.99 94
Mile High Compounds $69.99 94
Verified Peptides 20 mg $55.00 86
Peptidegurus 20 mg 84
Cocer Peptides 20 mg $160.00 82
NG Peptide 20 mg $60.00
Core Peptides 20 mg $63.00
Peptide Crafters 25 mg $55.00
Platinum Lion $64.99
Wellness Peptides $55.00

Research

Peptides (Epigenetic Regulators) in the Structure of Rodents with a Long and Short Lifespan
Khavinson VK, Kormilets DY, Mar'yanovich AT. · Bulletin of experimental biology and medicine (2017) · animal

We have discovered motives of short-chain epigenetically active peptides in some proteins of long-lived African mole rat Heterocephalus glaber. These epigenetic regulators are located in the protein structure between lysine and arginine residues, thus facilitating their release in limited proteolysis.

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[Deheterochromatinization of the chromatin in old age induced by oligopeptide bioregulator (Lys-Glu-Asp-Pro)]
Dzhokhadze TA, Buadze TZh, Gaĭozishvili MN, Baratashvili NA, Lezhava TA. · Georgian medical news (2012) ·

In this work is presented the data on the variability of the functional characteristics of the chromosomes in the cells exposed by oligopeptide bioregulator - Prostamax from old individuals (75-86 years).

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Microcalorimetric study of human blood lymphocytes culture at presence of copper, cadmium and prostamax
Kiladze M, Gorgoshidze M, Monaselidze J, Jokhadze T, Lezhava T. · Georgian medical news (2009) ·

Research goal was study of separate and joint influence of bioregulator prostamax and Cu(II) and Cd(II) ions on the chromatin structure in situ.

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[The tissue-specific effect of synthetic peptides-biologic regulators in organotypic tissues culture in young and old rats]
Zakutskiĭ AN, Chalisova NI, Ryzhak GA, Aniskina AI, Filippov SV, Zeziulin PN. · Advances in gerontology = Uspekhi gerontologii (2006) · animal

The synthetic peptides--cardiogen, bronchogen, prostamax and pancragen were used to investigate their effect on organotypic tissue culture of explants from heart, lungs, prostatic gland and pancreas of young (3-week old) and aged (18-month old) rats.

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[The influence of the peptide bioregulator prostamax on heterochromatin of human lymphocytes in situ]
Meskhi T, Khachidze D, Barbakadze Sh, Madzhagaladze G, Gorgoshidze M, Monaselidze D, Lezhava T, Tadumadze N. · Biofizika (2004) ·

It was shown that chromatin contained in human lymphocytes has two stages of denaturation: with T(d)VII = 94.4 degrees C, Q(d)VII = 50.8 J/g DNA, and T(d)VIII = 105.1 degrees C Q(d)VIII = 44.9 J/g DNA.

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Effects of short peptides on lymphocyte chromatin in senile subjects
Khavinson VKh, Lezhava TA, Malinin VV. · Bulletin of experimental biology and medicine (2004) ·

Effects of synthetic short peptides (Vilon, Epithalon, Livagen, Prostamax, and Cortagen) on activity of ribosome genes, parameters of common heterochromatin melting, polymorphism of structural heterochromatin (C segments) of chromosomes 1, 9, and 16, and variability of facultative heterochromatin were studied in leukoc…

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