Vesugen
aka Lys-Glu-Asp
Mechanism
Vesugen is a synthetic tripeptide, Lys-Glu-Asp (KED), from the Khavinson short-peptide 'bioregulator' series, positioned as a short-peptide analog of a bovine vascular-tissue polypeptide complex and claimed to be vasoprotective. Marketed on the Russian/Ukrainian grey market; not FDA-approved in the US; research-use only.
Identification
| CAS number | 204271-66-9 |
|---|---|
| Molecular formula | C15H26N4O8 |
| Sequence | KED |
| Typical dose | 1-2 mg/day subcutaneous (10-30 day cycles); 10-20 mg/day oral (research use only) |
| Half-life | ~30 minutes (estimated; short tripeptide) |
Vendors selling Vesugen
| Vendor | Size | Price | Listed purity | Trust |
|---|---|---|---|---|
| BioLongevity Labs | 20 mg | $84.97 | — | 96 |
| Orbitrex Peptides | 20 mg | $149.99 | — | 95 |
| Peptide Tech | 20 mg | $39.99 | — | 94 |
| Peptidology | 20 mg | $54.99 | — | 89 |
| Peptide Plugs | 20 mg | $50.00 | — | 89 |
| Verified Peptides | 20 mg | $60.00 | — | 86 |
| Peptidegurus | 20 mg | — | — | 84 |
| Core Peptides | 20 mg | $63.00 | — | — |
| Genetic Peptide | 10 mg | $35.00 | — | — |
| Genetic Peptide | 20 mg | $35.00 | — | — |
| Platinum Lion | — | $64.99 | — | — |
| Wellness Peptides | — | $65.00 | — | — |
Research
Neurons become more vulnerable to stress factors with age, which leads to increased oxidative DNA damage, decreased activity of mitochondria and lysosomes, increased levels of p16, decreased LaminB1 proteins, and the depletion of the dendritic tree.
source →Ultrashort peptides (USPs), consisting of 2-7 amino-acid residues, are a group of signaling molecules that regulate gene expression and protein synthesis under normal conditions in various diseases and ageing. USPs serve as a basis for the development of drugs with a targeted mechanism of action.
source →KED and EDR peptides prevent dendritic spines loss in amyloid synaptotoxicity in in vitro model of Alzheimer's disease (AD). The objective of this paper was to study epigenetic mechanisms of EDR and KED peptides' neuroprotective effects on neuroplasticity and dendritic spine morphology in an AD mouse model.
source →Peptides are characterized by their wide range of biological activity: they regulate functions of the endocrine, nervous, and immune systems.
source →We've estimated the cellular and metabolic part of geroprophylactic effects of short synthetic tripeptides vesugen and pinealon for correction of the biological age. 32 people (18 men, 12 women) aged 41-83 years with polymorbidity and the organic brain syndrome in remission participated in the study.
source →Short peptides vesugen and D-7 have stimulated proliferation-associated protein Ki-67 decreased during aging in tissue-specific cell cultures received from young and old animals and in dissociated vascular endothelial cell cultures.
source →We verified expression of CXCL12 and Hoxa3 transcription factors of differentiation in cultures of human embryonic pancreatic and bronchial cells and CXCL12 and WEGC1 factors in a culture of human prostatic fibroblasts. Reduced expression of these differentiation markers was detected in late-passage (aging) cultures.
source →We studied cell composition of the pineal lymphoid tissue and the effect of peptides on its differentiation and proliferation capacity.
source →Biological effects of short regulatory peptides, pinealon, vesugen, vilon and epitalon were studied in model experiments in vitro. These peptides were found not to demonstrate direct antioxidant activity but be able to restrict lipid peroxidation of human lipoproteins by modification of their structure.
source →The data presented suggest that short regulatory peptides (vilon, epitalon, vesugen and pinealon) have manifested the antihypoxic properties in the model of hypobaric hypoxia. Pinealon (Glu-Asp-Arg) has the most pronounced effect among them.
source →