Vasoactive Intestinal Peptide (VIP)
aka VIP
Mechanism
Vasoactive Intestinal Peptide (VIP) is a 28-amino acid neuropeptide of the secretin/glucagon family, widely distributed in the CNS and peripheral nervous system. It is a potent vasodilator, bronchodilator, and immunomodulator. Synthetic VIP (aviptadil) has been investigated in clinical trials for COVID-19-associated acute respiratory failure; it is NOT FDA-approved. Intranasal compounded VIP is used off-label in the controversial 'CIRS' (Chronic Inflammatory Response Syndrome) / mold-illness protocol popularized by Ritchie Shoemaker — CIRS is not a mainstream medical diagnosis.
Identification
| CAS number | 40077-57-4 |
|---|---|
| Molecular formula | C147H237N43O43S |
| Sequence | HSDAVFTDNYTRLRKQMAVKKYLNSILN |
| Typical dose | 50 mcg per nostril (400 mcg/day) intranasal 4x daily (Shoemaker/CIRS protocol); 25–50 mcg/kg inhaled q4–6h for pulmonary research |
| Half-life | ~1–2 minutes (plasma, IV/physiological conditions) |
Vendors selling Vasoactive Intestinal Peptide (VIP)
| Vendor | Size | Price | Listed purity | Trust |
|---|---|---|---|---|
| Peptide Partners | 20 mg | $150.00 | — | 99 |
| Moglabs | 5 mg | $36.00 | — | 96 |
| Crush Research | 10 mg | $43.00 | — | 95 |
| Orbitrex Peptides | 10 mg | $74.99 | — | 95 |
| Peptide Tech | 10 mg | $48.99 | — | 94 |
| Skye Peptides | 5 mg | $59.00 | — | 90 |
| Qihang Peptide | — | — | — | 87 |
| Peptidegurus | 6 mg | — | — | 84 |
| Cocer Peptides | 10 mg | $220.00 | — | 82 |
| Mandy | 10 mg | $136.00 | — | 43 |
| MJT peptides | 10 mg | $187.00 | — | 39 |
| NG Peptide | 10 mg | $45.00 | — | — |
Research
Patients infected with SARS-CoV-2 may develop mild respiratory symptoms but also Acute Respiratory Distress Syndrome (ARDS). Additionally, severe systemic inflammation contributes to morbidity and mortality.
source →Adipose tissue represents an organ that is highly dynamic and contributes toward vital survival events such as immune responses, lactation, metabolism fuel, and thermogenesis.
source →To clarify whether non-invasive neuromodulation for assisted bowel preparation can improve the quality of bowel preparation, to explore the possible mechanisms by which TEA improves the quality of bowel preparation, and to assess its safety, as well as subjects' tolerance, compliance and satisfaction.
source →Introduction Polycystic ovary syndrome (PCOS) is a common multifactorial and polygenic disorder of the endocrine system, affecting up to 20% of women in reproductive age with a still unknown etiology.
source →Objective This study aimed to investigate the potential involvement of vasoactive intestinal polypeptide (VIP) in myopia development and its contribution to the mechanism of action of the anti-myopia drug, atropine.
source →The amygdaloid complex, also known as the amygdala, is a heterogeneous group of distinct nuclear and cortical pallial and subpallial structures. The amygdala plays an important role in several complex functions including emotional behavior and learning.
source →This is a prospective, randomized, double-blind controlled trial. Elderly patients with constipation requiring colonoscopy were randomly divided into four groups: 1. Received both gastrointestinal external stimulation and transcutaneouselectrical acupoint stimulation; 2.
source →Vasoactive intestinal peptide (VIP) is a neuropeptide that play an important role in immunoregulation and anti-inflammation. Numerous inflammatory/autoimmune disorders are associated with decreased VIP binding ability to receptors and diminished VIP activation of cAMP generation in immune cells.
source →Polycystic Ovary Syndrome (PCOS) is a complex endocrine disorder characterized by hyperandrogenism, insulin resistance, and ovulatory dysfunction. One of the diagnostic criteria for PCOS is the presence of polycystic ovaries, which are enlarged ovaries with multiple follicles on ultrasound.
source →Aim of the study was to assess a potential dysfunction of the endocannabidiome system (eCBome) in migraine patients.
source →Vasoactive intestinal peptide (VIP), a member of secretin/glucagon family, is involved in a variety of biological activities such as gut motility, immune responses, and carcinogenesis.
source →Absence epilepsy is classified as a childhood generalized epilepsy syndrome with distinctive electroencephalographic patterns. The Wistar Albino Glaxo originating from Rijswijk (WAG/Rij) strain is a very well validated animal model of absence epilepsy that also shows behavioral deficits.
source →Circuit interactions within the medial entorhinal cortex (MEC) translate movement into a coherent code for spatial location. Entorhinal principal cells are subject to strong lateral inhibition, suggesting that a disinhibitory mechanism may drive their activation.
source →Acrylamide is one of the harmful substances present in food.
source →Novel Corona Virus (SARS-CoV-2) is known to cause Respiratory Failure, which is the hallmark of Acute COVID-19, as defined by the new NIH/FDA classification. Approximately 50% of those who develop Critical COVID-19 die, despite intensive care and mechanical ventilation.
source →VIP and its receptors (VPACRs) are largely investigated in vertebrate testis, as well as their functions in the control of spermatogenesis and steroidogenesis. By contrast, a few data are available about the presence and role of VIP in the epididymis.
source →An innovative method of needleless transcutaneous electroacupuncture (TEA) using a newly developed watch-size stimulator is proposed. Weak electrical current will be delivered via skin surface electrodes to acupuncture points related to gastrointestinal functions.
source →Sphenopalatine ganglion (SPG)-acupuncture has been shown to exhibit distinct effects in treatment of nasal inflammatory disease, but the mechanisms remain largely unknown. Investigators aimed to assess the effects of SPG acupuncture for nasal ventilation function and autonomic nervous system in health volunteers.
source →This study, a new immunomodulatory therapy of COPD with vasoactive intestinal peptide (VIP) was evaluated. Based on preliminary unpublished clinical and experimental results, the course of disease under VIP treatment and the molecular mechanisms involved were assessed.
source →