PE-22-28
aka PE 22-28
Mechanism
PE-22-28 is a 7-amino-acid synthetic analog of spadin, a peptide fragment (residues 22-28) of the 44-aa propeptide (PE) released during post-translational maturation of sortilin (the neurotensin receptor-3). It is studied in preclinical models as a fast-acting antidepressant that works by selectively blocking the TREK-1 two-pore potassium channel. There is no established use for hair growth — that is a separate compound and the two should not be confused.
Identification
| CAS number | 1801959-12-5 |
|---|---|
| Molecular formula | C35H55N11O9 |
| Sequence | GVSWGLR |
| Typical dose | 0.1–0.5 mg/kg subcutaneous in rodent models; no established human dose |
| Half-life | ~2–4 hours (rodent plasma; estimated from structurally similar peptides) |
Vendors selling PE-22-28
| Vendor | Size | Price | Listed purity | Trust |
|---|---|---|---|---|
| Ion Peptide | 10 mg | $49.00 | — | 95 |
| Peptide Tech | 10 mg | $49.99 | — | 94 |
| Mile High Compounds | — | $49.99 | — | 94 |
| Skye Peptides | 8 mg | $54.00 | — | 90 |
| Peptidology | 10 mg | $49.99 | — | 89 |
| Peptide Plugs | 10 mg | $40.00 | — | 89 |
| Simple Peptide | 10 mg | $72.00 | — | 85 |
| Peptidegurus | — | — | — | 84 |
| Cocer Peptides | — | $400.00 | — | 82 |
| AMC Essentials | 30 mg | $99.99 | — | — |
| AMC Essentials | 8 mg | $47.99 | — | — |
| Atomik Labz | 8 mg | $60.00 | — | — |
| Biotech Peptides | 8 mg | $55.00 | — | — |
| Core Peptides | 8 mg | $54.00 | — | — |
| Kimera Chems | — | $66.99 | — | — |
| Modern Research Peptides | 10 mg | $44.99 | — | — |
| Paramount Peptides | 10 mg | $50.00 | — | — |
| Peptira | — | $49.00 | — | — |
| Pepvida Labs | — | $118.00 | — | — |
| Polaris Peptides | 13 mg | $45.00 | — | — |
| Solution Peptides | 8 mg | $60.00 | — | — |
| Welli Labs | — | $49.99 | — | — |
Research
Objective To explore the effects of multivitamin combined with magnesium sulfate on placental hemodynamics, coagulation function, and maternal and infant outcomes in preeclampsia patients.
source →Mental health disorders are among the most common health conditions in the United States. Traditional clinical treatments rely on psychiatric counseling and, in many cases, prescription medications.
source →The role of artificial intelligence (AI) in healthcare for pregnant women. To assess the role of AI in women's health, discover gaps, and discuss the future of AI in maternal health. A systematic review of English articles using EMBASE, PubMed, and SCOPUS. Search terms included pregnancy and AI.
source →Background Studies have reported seasonal variations regarding the incidence and the short-term mortality of pulmonary embolism (PE). The aim of this study was to identify sex-specific and age-related differences in seasonal patterns regarding hospitalisations and mortality of PE patients.
source →TREK-1 is the most studied background K 2P channel. Its main role is to control cell excitability and maintain the membrane potential below the threshold of depolarization.
source →Depression is a devastating mental disorder that affects 20% of the population worldwide. Despite their proven efficacy, antidepressants present a delayed onset of action and serious adverse effects. Seven years ago, we described spadin (PE 12-28) as a promising endogenous peptide with antidepressant activity.
source →