Gonadorelin
aka GnRH
Mechanism
Gonadorelin is a synthetic decapeptide identical to endogenous gonadotropin-releasing hormone (GnRH/LHRH; sequence pyroGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2). It was historically FDA-approved as Factrel (diagnostic GnRH stimulation test) and Lutrepulse (pulsatile IV pump for hypothalamic amenorrhea); both products are discontinued in the US. Gonadorelin remains on the FDA Category 1 bulk substances list and is widely compounded, most commonly as an off-label adjunct to TRT intended to preserve HPG-axis signaling.
Identification
| CAS number | 33515-09-2 |
|---|---|
| Molecular formula | C55H75N17O13 |
| Sequence | QHWSYGLRPG |
| Typical dose | 100–250 mcg subcutaneous, 2–3x weekly (research use); 5–20 mcg/pulse every 90–120 min via pulsatile infusion pump for hypogonadotropic hypogonadism |
| Half-life | Distribution: 2–10 minutes; terminal: 10–40 minutes |
Vendors selling Gonadorelin
| Vendor | Size | Price | Listed purity | Trust |
|---|---|---|---|---|
| Peptide Tech | 2 mg | $29.99 | — | 94 |
| Peptidology | 5 mg | $39.99 | — | 89 |
| Peptidology | 11 mg | $39.99 | — | 89 |
| Qihang Peptide | — | — | — | 87 |
| Peptidegurus | 10 mg | — | — | 84 |
| Crystal Peptides | 5 mg | $49.00 | — | 66 |
| Peptiatlas | — | — | — | 51 |
| HongDa Peptide | — | $34.00 | — | 43 |
| zztai Peptide Ltd | — | — | — | 43 |
| MJT peptides | 2 mg | $38.00 | — | 39 |
| Biotech Peptides | 10 mg | $79.00 | — | — |
| Core Peptides | 10 mg | $90.00 | — | — |
| Genetic Peptide | 2 mg | $20.00 | — | — |
| Genetic Peptide | 10 mg | $20.00 | — | — |
| Kimera Chems | — | $31.99 | — | — |
| Modern Research Peptides | 5 mg | $32.99 | — | — |
| Oasis Labs | 10 mg | $84.00 | — | — |
| Paramount Peptides | 10 mg | $70.00 | — | — |
| Soma Peptides | 2 mg | $59.00 | — | — |
Research
The limited availability of gonadorelin has resulted in an increased use of subcutaneous triptorelin to diagnose central precocious puberty; however, studies validating its diagnostic value remain limited.
source →The aim of this study was to evaluate the effects of administering 325 mg of recombinant bovine somatotropin (rbST) at the initiation of the synchronization protocol (SYNCd) and/or on the day of embryo transfer (ETd) using a 2 × 2 experimental arrangement in Holstein heifer recipients.
source →The objective of this study was to evaluate the effect of administering 200 µg versus 100 µg of GnRH as gonadorelin hydrochloride (Factrel; Zoetis, Parsippany, NJ) at the first GnRH injection (G1) of the breeding Ovsynch in a Double-Ovsynch (DO) protocol on pregnancy per artificial insemination (P/AI) at first service…
source →Parental care enhances offspring survival but requires profound alteration of parental physiological and behavioural states.
source →The aim of this study was to compare pregnancy per AI (P/AI) in resynchronization (Resynch) protocols using different hormonal combinations (estradiol benzoate [EB], a double dose of GnRH, or EB with a double dose of GnRH) administered on the day of progesterone (P4) device insertion.
source →Queens are induced ovulators, and ovulatory success varies with hormonal status and stress.
source →Repeat-breeder cows (defined as having > 3 inseminations) significantly impact dairy profitability worldwide.
source →The objective was to evaluate the fertility of Bos indicus cows submitted to an ovulation synchronization protocol without estrogen (E2). In experiment 1, injectable P4 (P4i) was administered 10 days (D-10) before the TAI protocol.
source →Graphical abstract Abstract Central precocious puberty (CPP) results from premature activation of the hypothalamic-pituitary-gonadal axis. The GnRH stimulation test remains the diagnostic gold standard, especially in girls with undetectable basal LH levels. However, native GnRH is expensive and often unavailable.
source →Fixed-time artificial insemination (FTAI) is currently a standardized protocol for pig reproductive management. Efficient ovulation synchronization induced by GnRH analogs is critical for ensuring the pregnancy outcomes of FTAI.
source →In tambaqui (Colossoma macropomum), a rheophilic Amazonian fish of significant aquaculture importance that typically fails to spawn under captive conditions, gonadorelin has demonstrated potential in inducing ovulation and enabling strip spawning.
source →HSCT is an effective method to cure hematologic malignancies.
source →The overall aim of this project is to test the hypothesis that the addition of ADT to metastasis-directed radiotherapy (MDRT) in well-selected PCa patients with oligo-metastatic disease prolongs the metastases progression-free survival (MPFS) compared to MDRT alone.
source →To Prevent Chemotherapy Induced Ovarian Failure with the gonadotropin-releasing hormone Agonist Goserelin in Young female Lymphoma Cancer patients Receiving Chemotherapy
source →This trial investigates the effects of FE 999049 compared to placebo.
source →To assess the efficacy of triptorelin pamoate prolonged release (PR) 3-month formulation in Chinese female subjects with endometriosis by demonstrating the non-inferiority of triptorelin pamoate PR 3-month formulation injected once as compared to triptorelin acetate PR 1-month formulation injected 3 times consecutively…
source →The objective of this study was to evaluate the safety profile of ELIGARD® in ethnic Asian prostate cancer patients.
source →The purpose of this study was to determine whether treatment with tamoxifen or a non-steroidal aromatase inhibitors (NSAI) + goserelin + LEE011 prolonged progression-free survival (PFS) compared to treatment with tamoxifen or a NSAI + goserelin + placebo in premenopausal women with hormone receptor positive (HR+), huma…
source →The goal of this clinical research study is to learn if ipilimumab in combination with either Lupron® (leuprolide), Zoladex® (goserelin), or Firmagon® (degarelix) can affect prostate-specific antigen (PSA) levels in patients with prostate cancer.
source →