Pinealon
aka EDR
Mechanism
Pinealon is a synthetic tripeptide (Glu-Asp-Arg) from the Khavinson bioregulator series, studied for its potential role in regulating pineal gland function and neuroprotective signaling pathways in preclinical models.
Identification
| CAS number | 175175-23-2 |
|---|---|
| Molecular formula | C15H26N6O8 |
| Sequence | EDR |
| Typical dose | 200–500 mcg/day subcutaneous |
| Half-life | ~15–30 minutes (estimated; no formal human PK data) |
Vendors selling Pinealon
| Vendor | Size | Price | Listed purity | Trust |
|---|---|---|---|---|
| Peptide Partners | 20 mg | $100.00 | — | 99 |
| Glacier Aminos | 10 mg | $49.99 | — | 99 |
| BioLongevity Labs | 20 mg | $69.97 | — | 96 |
| Crush Research | 10 mg | $99.00 | — | 95 |
| Orbitrex Peptides | — | $34.99 | — | 95 |
| Ion Peptide | 10 mg | $45.00 | — | 95 |
| Licensed Peptides | 10 mg | $76.99 | — | 95 |
| Peptide Tech | 20 mg | $38.99 | — | 94 |
| Mile High Compounds | — | $49.99 | — | 94 |
| Riptide Wellness | — | $74.99 | — | 92 |
| Skye Peptides | 20 mg | $69.00 | — | 90 |
| Peptide Plugs | 10 mg | $40.00 | — | 89 |
| Verified Peptides | 20 mg | $55.00 | — | 86 |
| Simple Peptide | 10 mg | $50.00 | — | 85 |
| Peptidegurus | 16 mg | — | — | 84 |
| Peptidegurus | 20 mg | — | — | 84 |
| Ascension Peptides | 10 mg | $53.00 | — | 84 |
| Cocer Peptides | 20 mg | $160.00 | — | 82 |
| OROS Research | 20 mg | — | — | 79 |
| Qing Li Peptide | — | — | — | 63 |
| AMC Essentials | 10.56 mg | $45.00 | — | — |
| AMC Essentials | 20 mg | $69.99 | — | — |
| Alpha Omega | 10 mg | $50.00 | — | — |
| Atomik Labz | 15 mg | $66.00 | — | — |
| Atomik Labz | 15 mg | $59.00 | — | — |
| Biotech Peptides | 20 mg | $68.00 | — | — |
| Core Peptides | 20 mg | $75.00 | — | — |
| Flawless Compounds | — | — | — | — |
| Genetic Peptide | 20 mg | $20.00 | — | — |
| Genetic Peptide | 5 mg | $20.00 | — | — |
| Modern Research Peptides | 10 mg | $46.99 | — | — |
| Oneday Compounds | 10 mg | $49.99 | — | — |
| Peptide Crafters | 25 mg | $55.00 | — | — |
| Peptira | — | $49.00 | — | — |
| Platinum Lion | — | $64.99 | — | — |
| Solution Peptides | 15 mg | $66.00 | — | — |
| Solution Peptides | 15 mg | $59.00 | — | — |
| Soma Peptides | 20 mg | $59.00 | — | — |
| Southern Aminos | 10 mg | $74.25 | — | — |
| True Peptide | 10 mg | $45.00 | — | — |
| Welli Labs | — | $29.99 | — | — |
| Wellness Peptides | — | $55.00 | — | — |
Research
Therapeutic peptides are emerging as promising adjuncts in the management of orthopaedic injuries, grounded in their ability to modulate molecular signaling networks central to cellular medicine.
source →Neurons become more vulnerable to stress factors with age, which leads to increased oxidative DNA damage, decreased activity of mitochondria and lysosomes, increased levels of p16, decreased LaminB1 proteins, and the depletion of the dendritic tree.
source →Tetrapeptide Asp-Arg-Glu-Leu (DREL) was isolated from Jiuzao protein hydrolysates (JPHs) by alkaline proteinase (AP) and exhibited antioxidant activity in the HepG2 cell model in the previous study.
source →The EDR peptide (Glu-Asp-Arg) has been previously established to possess neuroprotective properties. It activates gene expression and synthesis of proteins, involved in maintaining the neuronal functional activity, and reduces the intensity of their apoptosis in in vitro and in vivo studies.
source →The interaction of the regulatory biologically active peptide Glu-Asp-Arg (EDR) with DNA is considered by spectral, NMR, viscosimetry, and molecular dynamics methods. It was shown that EDR can partly penetrate into the major groove of DNA and affect the base atoms, mainly the N7 and O6 of guanine.
source →In the monitoring process 110 representatives of different age groups held a comparative analysis of the efficacy and safety of several geroprotective techniques, including the use of dry carbon dioxide baths, hyperbaric oxygen therapy, therapeutic massage and receiving Oligopeptide preparations containing complexes ly…
source →The research of Cortexin and Pinealon within two models of stress, acute hypobaric hypoxia and mild hypothermia, within 18-month aged rats has been held. The peculiarities of peptide preparations' influence on behavior and neurochemical indeces have been identified.
source →We've estimated the cellular and metabolic part of geroprophylactic effects of short synthetic tripeptides vesugen and pinealon for correction of the biological age. 32 people (18 men, 12 women) aged 41-83 years with polymorbidity and the organic brain syndrome in remission participated in the study.
source →While studying the effects of Cortexin and Pinealon (Glu-Asp-Arg) on the caspase-3 activity in the brain, an interleykin-6 and a factor of tumor necrosis in blood serum of old rats under the sharp hypoxic hypoxia it was suggested that in hypoxia of brain conditions Pinealon forwards the increase of the neurogenesis and…
source →The offspring of rats with experimental hyperhomocysteinemia caused by alimentary loading with dietary methionine within pregnancy has been studied.
source →The unfavorable factors of professional work of workers of locomotive brigades influence on speed of aging and adaptation possibilities of an organism.
source →The synthetic tripeptide pinealon (Glu-Asp-Arg) demonstrates dose-dependent restriction of reactive oxygen species (ROS) accumulation in cerebellar granule cells, neutrophils, and pheochromocytoma (PC12) cells, induced by oxidative stress stimulated by receptor-dependent or -independent processes.
source →