Thymalin
aka thymalinum
Mechanism
Thymalin is a heterogeneous polypeptide extract from calf thymus (a mixture, not a single defined peptide) developed in the 1970s by V. Kh. Khavinson and V. G. Morozov at the Military Medical Academy / St. Petersburg Institute of Bioregulation and Gerontology. Registered as a pharmaceutical in the USSR/Russia for immunocorrection. Distinct from Thymulin (Bach's zinc-dependent nonapeptide pGlu-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn, originally called FTS) and from Thymosin alpha-1 (a 28-amino-acid synthetic peptide). Not FDA-approved in the US; research-use only.
Identification
| Typical dose | 5-10 mg/day intramuscular or subcutaneous, for 10-20 consecutive days per cycle |
|---|---|
| Half-life | ~30 minutes (peptide components); biological effects persist 48-72 hours |
Vendors selling Thymalin
| Vendor | Size | Price | Listed purity | Trust |
|---|---|---|---|---|
| Ion Peptide | 10 mg | $59.00 | — | 95 |
| Peptide Tech | 20 mg | $39.99 | — | 94 |
| Peptidology | 10 mg | $54.00 | — | 89 |
| Peptide Plugs | 20 mg | $50.00 | — | 89 |
| Qihang Peptide | — | — | — | 87 |
| Verified Peptides | 10 mg | $36.00 | — | 86 |
| Peptidegurus | 20 mg | — | — | 84 |
| Qing Li Peptide | — | — | — | 63 |
| Peptiatlas | — | — | — | 51 |
| Mandy | 10 mg | $49.00 | — | 43 |
| HongDa Peptide | — | $74.00 | — | 43 |
| zztai Peptide Ltd | — | — | — | 43 |
| MJT peptides | 10 mg | $65.00 | — | 39 |
| Strate Labs | 20 mg | $39.95 | — | — |
| Atomik Labz | 10 mg | $65.00 | — | — |
| Biotech Peptides | 25 mg | $114.00 | — | — |
| Core Peptides | 25 mg | $138.00 | — | — |
| Genetic Peptide | 10 mg | $60.00 | — | — |
| Modern Research Peptides | 10 mg | $45.99 | — | — |
| Paramount Peptides | 20 mg | $95.00 | — | — |
| Peptide Crafters | 10 mg | $45.00 | — | — |
| Peptira | — | $59.00 | — | — |
| Solution Peptides | 10 mg | $65.00 | — | — |
| Soma Peptides | 100 mg | $152.00 | — | — |
| Southern Aminos | 10 mg | $59.25 | — | — |
Research
Leukopenia remains a major clinical challenge associated with infectious diseases, oncological therapies, autoimmune disorders, and metabolic and iatrogenic conditions.
source →The COVID-19 pandemic highlighted the potential of peptide-based therapies as an alternative to traditional pharmaceutical treatments for SARS-CoV-2 and its variants. Our review explores the role of therapeutic peptides in modulating immune responses, inhibiting viral entry, and disrupting replication.
source →Objective Aim of the study was to identify the morphological features of reparative osteogenesis in the lower jaw bone of rats in cases of filling a bone defect with hydroxyapatite-containing osteotropic material (bone graft "Biomin GT") and injecting the surrounding soft tissues with thymalin.
source →Objective Aim: The purpose of the study was to determine the features of the expression of T-lymphocytes, B-lymphocytes, macrophages in the post-traumatic regenerate of the mandible rats under conditions of filling a bone defect with hydroxyapatite-containing osteotropic material and thymalin injecting the surrounding…
source →Thymalin is an immunomodulatory drug containing a polypeptide extract of thymus that has demonstrated efficacy in the therapy of acute respiratory distress syndrome and chronic obstructive pulmonary disease, as well as in complex therapy related to severe COVID-19 in middle-aged and elderly patients..
source →The aim of the work was a comparative study of Tocilizumab and Thymalin effects on the morphological composition and indicators of the blood clotting system in COVID-19 of middle aged and elderly patients.
source →This study evaluates the effects of five different peptides, the Epitalon ® tetrapeptide, the Vilon ® dipeptide, the Thymogen ® dipeptide, the Thymalin ® peptide complex, and the Chonluten ® tripeptide, as regulators of inflammatory and proliferative processes in the human monocytic THP-1, which is a human leukemia mon…
source →The paper presents the results of a standard and complex treatment method using the peptide drug thymus thymalin in patients with COVID-19.
source →Thymalin is a polypeptide complex isolated from the thymus and regulating the functions of the immune system. Thymalin is effective in therapy of acute respiratory syndrome, chronic obstructive bronchitis, and other immunopathology.
source →There is a vast practice of using antimalarial drugs, RAS inhibitors, serine protease inhibitors, inhibitors of the RNA-dependent RNA polymerase of the virus and immunosuppressants for the treatment of the severe form of COVID-19, which often occurs in patients with chronic diseases and older persons.
source →