GHK
aka Glycyl-L-Histidyl-L-Lysine
Mechanism
GHK is the parent tripeptide Gly-His-Lys, originally isolated from human plasma by Loren Pickart (1973) as an activity that caused aged hepatocytes to synthesize proteins like younger tissue. It is DISTINCT from GHK-Cu, the 1:1 copper(II) complex tracked as a separate entry — but GHK binds copper readily in vivo, so in physiological environments the bare peptide rapidly associates with available Cu(II). Not FDA-approved for any indication; used in cosmetic and research contexts only.
Identification
| CAS number | 49557-75-7 |
|---|---|
| Molecular formula | C14H24N6O4 |
| Sequence | GHK |
| Typical dose | 1-2 mg/day subcutaneous injection (research protocols) |
| Half-life | ~30-60 minutes |
Vendors selling GHK
| Vendor | Size | Price | Listed purity | Trust |
|---|---|---|---|---|
| Glacier Aminos | 2 mg | $79.99 | — | 99 |
| Glacier Aminos | — | $39.99 | — | 99 |
| BioLongevity Labs | — | $199.97 | — | 96 |
| BioLongevity Labs | 50 mg | $84.97 | — | 96 |
| Reta One Labs | — | $39.00 | — | 95 |
| Reta One Labs | 80 mg | $79.00 | — | 95 |
| Reta One Labs | 70 mg | $67.00 | — | 95 |
| Licensed Peptides | 100 mg | $674.95 | — | 95 |
| Licensed Peptides | 50 mg | $359.95 | — | 95 |
| Hydro Research Peptides | 100 mg | $0.55 | — | 91 |
| Skye Peptides | 100 mg | $59.00 | — | 90 |
| Peptidology | 61 mg | $44.99 | — | 89 |
| Peptide Plugs | 60 mg | $55.00 | — | 89 |
| Sunrise Bioresearch | 250 mg | $116.31 | — | 88 |
| Verified Peptides | 100 mg | $49.99 | — | 86 |
| EZ Peptides | 100 mg | $53.00 | — | 85 |
| EZ Peptides | 50 mg | $35.00 | — | 85 |
| Simple Peptide | 50 mg | $65.00 | — | 85 |
| Simple Peptide | — | $140.00 | — | 85 |
| Simple Peptide | — | $115.00 | — | 85 |
| Peptidegurus | 50 mg | — | — | 84 |
| Ascension Peptides | 50 mg | $125.00 | — | 84 |
| Ascension Peptides | 50 mg | $125.00 | — | 84 |
| Ascension Peptides | 100 mg | $65.00 | — | 84 |
| MedGe Peptides | 50 mg | $50.00 | — | 82 |
| Texpeptide | 100 mg | $50.00 | — | 70 |
| AMC Essentials | 100 mg | $54.99 | — | — |
| AMC Essentials | 35 mg | $69.99 | — | — |
| Alpha Omega | 50 mg | $65.00 | — | — |
| Alpha Omega | — | $140.00 | — | — |
| Alpha Omega | — | $115.00 | — | — |
| Amino Sequence | 50 mg | $85.00 | — | — |
| Atomik Labz | 100 mg | $66.00 | — | — |
| Atomik Labz | 100 mg | $66.00 | — | — |
| Atomik Labz | 100 mg | $55.00 | — | — |
| Atomik Labz | 100 mg | $55.00 | — | — |
| Biotech Peptides | 200 mg | $165.00 | — | — |
| Biotech Peptides | 50 mg | $51.00 | — | — |
| Biotech Peptides | 200 mg | $186.00 | — | — |
| Biotech Peptides | 50 mg | $64.00 | — | — |
| Bulk Peptides | 100 mg | $200.00 | — | — |
| Bulk Peptides | 50 mg | $110.00 | — | — |
| Core Peptides | 200 mg | $197.00 | — | — |
| Core Peptides | 200 mg | $157.00 | — | — |
| Core Peptides | 50 mg | $49.00 | — | — |
| Core Peptides | 50 mg | $58.00 | — | — |
| Genetic Peptide | 50 mg | $70.00 | — | — |
| Genetic Peptide | 100 mg | $70.00 | — | — |
| Genetic Peptide | 2 mg | $155.00 | — | — |
| Kimera Chems | — | $56.99 | — | — |
| Modern Research Peptides | 10 mg | $59.99 | — | — |
| Nextech Labs | 100 mg | $75.00 | — | — |
| Oasis Labs | 10 mg | $104.50 | — | — |
| Oasis Labs | 10 mg | $126.00 | — | — |
| Oneday Compounds | 80 mg | $99.99 | — | — |
| Oneday Compounds | 70 mg | $79.99 | — | — |
| Paramount Peptides | 50 mg | $50.00 | — | — |
| Paramount Peptides | 100 mg | $75.00 | — | — |
| Peptide Crafters | 100 mg | $45.00 | — | — |
| Pepvida Labs | 100 mg | $36.25 | — | — |
| Polaris Peptides | 50 mg | $40.00 | — | — |
| Polaris Peptides | — | $30.00 | — | — |
| S1 Research | — | $26.00 | — | — |
| Solution Peptides | 100 mg | $66.00 | — | — |
| Solution Peptides | 100 mg | $66.00 | — | — |
| Solution Peptides | 100 mg | $55.00 | — | — |
| Solution Peptides | 100 mg | $55.00 | — | — |
| Soma Peptides | — | $89.00 | — | — |
| Soma Peptides | — | $129.00 | — | — |
| Southern Aminos | — | $56.25 | — | — |
| True Peptide | — | $100.00 | — | — |
| Welli Labs | — | $69.99 | — | — |
Research
The goal of this clinical trial is to investigate GHK and GHK-Cu blood levels pre- and post-intervention in healthy adults, and to investigate the efficacy of X39 patch on GHK and GHK-Cu blood levels in healthy adults compared to a placebo.
source →Sponge spicules have emerged as promising biomaterial scaffolds due to their biocompatibility and unique structural properties; however, achieving stable and bioactive functionalization remains a key challenge.
source →Starvation therapy has emerged as a promising strategy in diabetic wounds treating by regulating glucose level to deplete microbial nutrients without inducing antimicrobial resistance. However, this process consumes large amounts of oxygen, exacerbating wound hypoxia and compromising therapeutic efficacy.
source →Aging is a complex biological process characterized by progressive functional decline across tissues and increased susceptibility to age-related diseases, with oxidative stress being a key contributing factor.
source →Laccase plays an important role in the detection and degradation of phenolic compounds, but it is limited by its cost and stability. In this study, the laccase-like property of copper peptide (GHK-Cu) has been revealed.
source →Inflammation serves as a basic defense mechanism against both internal and external threats, while the unresolved or excessive inflammation can lead to irreversible tissue damage.
source →Radiotherapy is essential for cancer treatment, yet radiation-induced skin injury (RISI) remains a major clinical challenge due to reactive oxygen species (ROS) accumulation, metabolic dysregulation, and the limited efficacy of single-modality therapies in modulating the oxidative-inflammatory microenvironment.
source →Carbonless biomolecular design, in which carbon atoms are systematically replaced by boron and nitrogen under an isoelectronicity constraint, offers a route to carbon free analogues that retain the structural logic of familiar biochemistry.
source →Aims The mechanism of isosmotic water reabsorption in the kidney proximal tubule, with a focus on the interaction between the lateral Na + /K + -ATPase, apical water pathways mediated by AQP1 and SGLT1, and paracellular water flow through Claudin-2.
source →This study aimed to assess the influence of reduced exposure parameters on the reproducibility of two radiographic dental age assessment methods in panoramic radiographs: the staging system (GHK) proposed by Gleiser and Hunt (1955) modified by Köhler et al. (1994) and the metric method by Cameriere et al. (2008) (I3M).
source →Our double hit model is more robust in inducing behavioural and molecular changes involved in the negative and cognitive symptoms of schizophrenia when compared to each single hit model.
source →This study will evaluate whether a topical gel containing GHK-Cu (a copper(II)-peptide complex) can safely speed up healing of small, standardized skin wounds in healthy adults compared with a matching vehicle gel.
source →Precision Robotics' Sirius Robotic Flexible Endoscopic System is a new fully integrated compact 3D laparoscopic camera system with a disposable single-use flexible tip that can change its viewing direction.
source →The GHK intervention was developed according to the United Kingdom Medical Research Council's framework for developing and evaluating complex interventions. A pilot- and feasibility study was conducted during December 2022-April 2023, and the intervention was subsequently adapted and adjusted.
source →This is a phase IV, unblinded, open-label study assessing the impact on skin quality, hydration, and barrier of three (3) Hydrafacial treatments in healthy adults of Fitzpatrick Skin Types I \& II, III, IV, V \& VI, 30 to 55 years of age.
source →