GHRP-6
aka Growth Hormone Releasing Peptide-6
Mechanism
GHRP-6 is a synthetic hexapeptide (His-D-Trp-Ala-Trp-D-Phe-Lys-NH2) growth hormone secretagogue and ghrelin receptor agonist. Developed by Bowers and Momany and first described in 1984, it was the first synthetic GHRP characterized and is defined by its pronounced appetite-stimulating effect — the strongest of any clinically studied GHRP. It has never been approved by the FDA or any regulatory agency and remains a research-only compound used off-label in the grey market.
Identification
| CAS number | 87616-84-0 |
|---|---|
| Molecular formula | C46H56N12O6 |
| Sequence | HWAWFK |
| Typical dose | 100–300 mcg subcutaneous, 2–3x daily |
| Half-life | ~2.5 hours (elimination half-life; distribution half-life ~7.6 minutes, from human PK study) |
Vendors selling GHRP-6
| Vendor | Size | Price | Listed purity | Trust |
|---|---|---|---|---|
| Moglabs | 5 mg | $16.00 | — | 96 |
| Ion Peptide | 5 mg | $29.00 | — | 95 |
| Peptide Tech | — | $19.99 | — | 94 |
| Riptide Wellness | — | $39.99 | — | 92 |
| Qihang Peptide | — | — | — | 87 |
| Simple Peptide | — | $39.00 | — | 85 |
| Peptidegurus | 5 mg | — | — | 84 |
| Peptidegurus | 10 mg | — | — | 84 |
| Crystal Peptides | 5 mg | $29.99 | — | 66 |
| Qing Li Peptide | — | — | — | 63 |
| Certified Peptides | 10 mg | $48.00 | — | 62 |
| Nox Amino | 10 mg | $50.00 | — | 55 |
| Peptiatlas | — | — | — | 51 |
| DongCheng Peptide | — | — | — | 46 |
| Mandy | 5 mg | $21.00 | — | 43 |
| HongDa Peptide | — | $29.00 | — | 43 |
| HongDa Peptide | — | $29.00 | — | 43 |
| zztai Peptide Ltd | — | — | — | 43 |
| MJT peptides | 5 mg | $24.00 | — | 39 |
| Alpha Omega | — | $39.00 | — | — |
| Atomik Labz | 10 mg | $39.00 | — | — |
| Biotech Peptides | 5 mg | $21.00 | — | — |
| Biotech Peptides | 10 mg | $39.00 | — | — |
| Core Peptides | 10 mg | $20.00 | — | — |
| Core Peptides | 5 mg | $20.00 | — | — |
| Genetic Peptide | 5 mg | $33.00 | — | — |
| Genetic Peptide | 10 mg | $33.00 | — | — |
| Kimera Chems | 5 mg | $21.99 | — | — |
| Modern Research Peptides | 5 mg | $24.99 | — | — |
| Oasis Labs | 10 mg | $47.00 | — | — |
| Peptira | — | $34.00 | — | — |
| Solution Peptides | 10 mg | $39.00 | — | — |
| Solution Peptides | 5 mg | $19.00 | — | — |
| Soma Peptides | 10 mg | $29.00 | — | — |
Research
Background/Objective : GHRP-6 is a GH secretagogue hexapeptide with expanding and promising cardioprotective effects.
source →Acute lung injury/acute respiratory distress syndrome is a complex, characterized by acute onset, alveolar damage, and progressive hypoxemia. The subsequent proliferative phase drives to pulmonary fibrosis.
source →Renal tubular epithelial cells (TECs), which are highly susceptible to injury during acute kidney injury (AKI), have notable regenerative effects on renal recovery after AKI. AKI-driven metabolic reprogramming of TECs plays a critical role in determining whether kidneys recover functionally or develop fibrosis.
source →Growth hormone-releasing peptide 6 (GHRP-6), is a six-amino acid synthetic peptide that acts as a ghrelin analog and has shown growth-promoting and immunomodulatory activities in several fish species.
source →The aquaculture industry has experienced considerable growth in recent decades, stimulating research into sustainable and functional feed formulations, mainly related to using high-quality, safe, and environmentally friendly feed ingredients.
source →Background/Objectives: Ghrelin and growth hormone-releasing peptide 6 (GHRP-6) are peptides which can stimulate GH release, acting through the same receptor. Ghrelin and its receptor have been involved in reward sensation and addiction induced by natural and artificial drugs, including nicotine.
source →Introduction: Dilated cardiomyopathy (DCM) is a fatal myocardial condition with ventricular structural changes and functional deficits, leading to systolic dysfunction and heart failure (HF). DCM is a frequent complication in oncologic patients receiving Doxorubicin (Dox).
source →Despite its central role in regulating energy intake and metabolism, ghrelin is little understood when it comes to its effects on hepatic lipid and glucose metabolism.
source →Ghrelin is a gut hormone related to energy balance and reproductive functions.
source →Background and aims Scavenger receptor class B member 3, also known as cluster of differentiation-36 (CD36) receptor, is involved in the uptake and accumulation of modified lipoprotein in macrophages, driving atherosclerosis progression.
source →Antagonism of the functional ghrelin receptors impairs memory formation, but the underlying mechanisms are not well-known.
source →Alcoholic steatosis, characterized by an accumulation of triglycerides in hepatocytes, is one of the earliest pathological changes in the progression of alcoholic liver disease. In our previous study, we showed that alcohol-induced increase in serum ghrelin levels impair insulin secretion from pancreatic β-cells.
source →