Kisspeptin-10
aka KP-10
Mechanism
Kisspeptin-10 (KP-10) is the 10-amino-acid C-terminal fragment of kisspeptin (the KISS1 gene product, also called metastin) that retains full biological activity. It is an investigational signaling peptide that sits at the top of the reproductive axis and is studied for fertility, hypogonadism, and as a diagnostic challenge. It is not FDA-approved.
Identification
| CAS number | 374675-21-5 |
|---|---|
| Molecular formula | C63H83N17O14 |
| Sequence | YNWNSFGLRF |
| Typical dose | 50–300 mcg per injection subcutaneous/IV (research use); clinical IV infusion protocols vary widely |
| Half-life | ~4 minutes (human, intravenous; post-infusion t½ reported as 3.8–4.1 min) |
Vendors selling Kisspeptin-10
| Vendor | Size | Price | Listed purity | Trust |
|---|---|---|---|---|
| BioLongevity Labs | 10 mg | $64.97 | — | 96 |
| Orbitrex Peptides | 10 mg | $69.99 | — | 95 |
| Profound Aminos | 10 mg | $49.00 | — | 95 |
| Licensed Peptides | 5 mg | $68.99 | — | 95 |
| Licensed Peptides | 10 mg | $68.99 | — | 95 |
| Peptide Tech | 10 mg | $48.99 | — | 94 |
| Riptide Wellness | — | $59.99 | — | 92 |
| Skye Peptides | 10 mg | $49.00 | — | 90 |
| Peptide Plugs | 10 mg | $50.00 | — | 89 |
| Qihang Peptide | — | — | — | 87 |
| Peptidegurus | 5 mg | — | — | 84 |
| Reta Peptide | — | — | — | 83 |
| OROS Research | 5 mg | — | — | 79 |
| Crystal Peptides | 10 mg | $34.99 | — | 66 |
| Certified Peptides | 5 mg | $52.00 | — | 62 |
| Nox Amino | 10 mg | $55.00 | — | 55 |
| Peptiatlas | — | — | — | 51 |
| MEI-PEPETIDE | 5 mg | $51.00 | — | 48 |
| DongCheng Peptide | — | — | — | 46 |
| Mandy | 5 mg | $41.00 | — | 43 |
| HongDa Peptide | — | $71.00 | — | 43 |
| zztai Peptide Ltd | — | — | — | 43 |
| MJT peptides | 5 mg | $65.00 | — | 39 |
| Cernum Biosciences | 5 mg | $59.99 | — | — |
| Cernum Biosciences | 10 mg | $74.99 | — | — |
| NG Peptide | 10 mg | $35.00 | — | — |
| AMC Essentials | 5 mg | $37.99 | — | — |
| Biotech Peptides | 10 mg | $52.00 | — | — |
| Core Peptides | 10 mg | $63.00 | — | — |
| Genetic Peptide | 5 mg | $65.00 | — | — |
| Genetic Peptide | 10 mg | $65.00 | — | — |
| Kimera Chems | — | $71.99 | — | — |
| Oasis Labs | 5 mg | $52.50 | — | — |
| Peptide Crafters | 5 mg | $30.00 | — | — |
| Soma Peptides | 5 mg | $39.00 | — | — |
Research
Background Cardiac fibroblasts play a key role in extracellular matrix (ECM) remodelling through the synthesis of glycosaminoglycans and proteoglycans (PGs), such as decorin; however, the effects of kisspeptin-10 (KiSS-10) on these components in the heart remain unknown.
source →The discovery of the neuropeptide kisspeptin (Kp) and its receptor has attracted considerable attention as a potential therapeutic target for the treatment of various medical disorders and for the management of reproduction in livestock.
source →Background Distinguishing idiopathic central precocious puberty (ICPP) from premature thelarche (PT) remains a clinical challenge and often necessitates GnRH stimulation testing.
source →Ovarian cancer is one of the deadliest female gynaecological cancers, known to have high metastatic ability and telomerase reactivation.
source →Introduction Kisspeptin (KiSS), neurokinin B (NKB) and dynorphin A (Dyn A) participate in the neuroendocrine regulation of reproductive system development and functioning; however, their roles in the onset of sexual maturity and pathomechanism of delayed puberty have not yet been fully elucidated.
source →Mitochondrial dysfunction and dysregulated mitophagy in pulmonary artery smooth muscle cells (PASMCs) critically drive pulmonary arterial hypertension (PAH). Here we show that Kisspeptin-10, acting via its receptor GPR54, markedly attenuates PAH in the SU5416/hypoxia mouse model.
source →Objectives The present study aimed to comprehensively elucidate how KP-10 modulates hormone secretion, the proliferation and autophagy of ovarian follicles by regulating in-vivo and in-vitro levels of associated genes and proteins. Methods Follicular granulosa cells (FGCs) were cultured in EMDM/F12 medium.
source →Glioblastoma multiforme (GB) is the most aggressive and lethal primary brain tumor, with limited biomarkers for diagnosis and therapeutic targeting.
source →Background Microglial NLRP3 inflammasome activation plays a central role in the neuroinflammatory cascade that contributes to the pathogenesis of various neurodegenerative diseases.
source →The integrity of the Blood-Brain Barrier (BBB) is crucial in the pathophysiological progression of acute ischemic stroke (AIS). However, the potential of Kisspeptin-10 (Kp-10), with its antioxidant and anti-inflammatory properties, has not been explored experimentally in the context of stroke management.
source →Aims Cerebral aneurysms (CAs) are a prevalent brain condition with poorly understood pathological features. The Kisspeptin-10 (KP-10)/G protein-coupled receptor 54 (GPR54) system is a vital neuroendocrine pathway primarily implicated in the regulation of reproductive functions and energy metabolism.
source →Kisspeptin is a neuropeptide recognised for a pivotal role within the reproductive system, but potentially important endocrine metabolic effects are less well understood.
source →The goal of this study is to understand how exogenous kisspeptin affects metabolism by evaluating responses to an hyperglycemic clamp
source →This study utilizes infusions of kisspeptin in healthy women to isolate the impact of kisspeptin on beta-cell responsivity assessed by the mixed meal tolerance test.
source →The present study was designed to assess the responsiveness of the hypothalamic pituitary gonadal axis to kisspeptin administration with increasing age in men.
source →The specific objective of this study was to investigate the sensitivity of Kisspeptin receptor 1 (KISS1R) by determining the responsiveness of GnRH neuron to kisspeptin administration across the pubertal stages and adult group through measuring plasma LH (luteinizing hormone) and testosterone concentrations.
source →Induction of insulin secretion by kisspeptin is observed in mouse, pig, rat, and human islets in vitro and in rats, mice and monkeys in vivo, but its mechanism is not fully clear. The present study was designed to investigate the role of KP-10 on insulin secretion in adult healthy and obese men with insulin resistance.
source →