Sermorelin
aka Geref
Mechanism
Sermorelin is a synthetic analog of growth hormone-releasing hormone (GHRH) consisting of the first 29 amino acids of the 44-aa native hormone — the shortest fragment that retains full biological activity. It was FDA-approved in the 1990s as Geref (EMD Serono) for diagnostic testing of pituitary GH reserve and later for pediatric idiopathic GH deficiency, but was withdrawn from the US market in 2008–2009 at the manufacturer's request for commercial reasons (not safety or efficacy). It remains on the FDA Category 1 list of bulk substances nominated for use in 503A compounding, where it is now widely prescribed off-label for adult GH insufficiency and "anti-aging" indications.
Identification
| CAS number | 86168-78-7 |
|---|---|
| Molecular formula | C149H246N44O42S |
| Sequence | YADAIFTNSYRKVLGQLSARKLLQDIMSR |
| Typical dose | 200-500 mcg/day subcutaneous injection, typically administered at bedtime |
| Half-life | ~10-20 minutes (plasma elimination half-life after subcutaneous administration) |
Vendors selling Sermorelin
| Vendor | Size | Price | Listed purity | Trust |
|---|---|---|---|---|
| Peptide Partners | 20 mg | $115.00 | — | 99 |
| Glacier Aminos | 10 mg | $62.99 | — | 99 |
| Crush Research | 10 mg | $43.00 | — | 95 |
| Orbitrex Peptides | 10 mg | $79.99 | — | 95 |
| Profound Aminos | 5 mg | $43.00 | — | 95 |
| Licensed Peptides | 5 mg | $404.95 | — | 95 |
| Licensed Peptides | 5 mg | $68.99 | — | 95 |
| Licensed Peptides | 10 mg | $68.99 | — | 95 |
| Prime Peptides | 10 mg | $65.00 | — | 95 |
| Peptide Tech | 5 mg | $33.99 | — | 94 |
| Mile High Compounds | — | $69.99 | — | 94 |
| Hydro Research Peptides | 10 mg | $0.64 | — | 91 |
| Skye Peptides | 5 mg | $49.00 | — | 90 |
| Peptidology | 10 mg | $79.95 | — | 89 |
| Peptide Plugs | 10 mg | $55.00 | — | 89 |
| Qihang Peptide | — | — | — | 87 |
| EZ Peptides | 5 mg | $44.00 | — | 85 |
| Simple Peptide | 5 mg | $49.00 | — | 85 |
| Simple Peptide | 10 mg | $49.00 | — | 85 |
| Peptidegurus | 2 mg | — | — | 84 |
| Peptidegurus | 5 mg | — | — | 84 |
| Ascension Peptides | 10 mg | $72.00 | — | 84 |
| Reta Peptide | — | — | — | 83 |
| Blank Peptides | 10 mg | $70.00 | — | 81 |
| OROS Research | 5 mg | — | — | 79 |
| OROS Research | 5 mg | — | — | 79 |
| Texpeptide | 10 mg | $50.00 | — | 70 |
| Crystal Peptides | 10 mg | $59.99 | — | 66 |
| Certified Peptides | 10 mg | $95.00 | — | 62 |
| Certified Peptides | 5 mg | $60.00 | — | 62 |
| Nox Amino | 10 mg | $55.00 | — | 55 |
| Peptiatlas | — | — | — | 51 |
| MEI-PEPETIDE | 2 mg | $32.00 | — | 48 |
| DongCheng Peptide | — | — | — | 46 |
| Mandy | 5 mg | $56.00 | — | 43 |
| HongDa Peptide | — | $80.00 | — | 43 |
| MJT peptides | 5 mg | $73.00 | — | 39 |
| HK Peptide Ltd (hk peptides) | — | — | — | 37 |
| Cernum Biosciences | 5 mg | $52.99 | — | — |
| Cernum Biosciences | 10 mg | $79.99 | — | — |
| NG Peptide | 10 mg | $45.00 | — | — |
| Strate Labs | 10 mg | $99.95 | — | — |
| AMC Essentials | 10 mg | $65.99 | — | — |
| Alpha Omega | 5 mg | $49.00 | — | — |
| Alpha Omega | 10 mg | $49.00 | — | — |
| Atomik Labz | 10 mg | $74.00 | — | — |
| Atomik Labz | 10 mg | $64.00 | — | — |
| Biotech Peptides | 9 mg | $88.00 | — | — |
| Biotech Peptides | 5 mg | $43.00 | — | — |
| Biotech Peptides | 10 mg | $81.00 | — | — |
| Core Peptides | 9 mg | $85.00 | — | — |
| Core Peptides | 10 mg | $88.00 | — | — |
| Core Peptides | 10 mg | $88.00 | — | — |
| Core Peptides | 10 mg | $80.00 | — | — |
| Core Peptides | 5 mg | $48.00 | — | — |
| Felix Chemical Supply | 10 mg | $69.99 | — | — |
| Flawless Compounds | — | — | — | — |
| Genetic Peptide | 5 mg | $55.00 | — | — |
| Genetic Peptide | 10 mg | $165.00 | — | — |
| Genetic Peptide | 10 mg | $95.00 | — | — |
| Genetic Peptide | 9 mg | $95.00 | — | — |
| Genetic Peptide | 2 mg | $35.00 | — | — |
| Genetic Peptide | 18 mg | $200.00 | — | — |
| Ignite Peptides | 5 mg | $50.00 | — | — |
| Kimera Chems | — | $46.99 | — | — |
| Modern Research Peptides | 5 mg | $39.99 | — | — |
| Modern Research Peptides | 10 mg | $46.99 | — | — |
| Nextech Labs | 10 mg | $75.00 | — | — |
| Nova Peptides | 5 mg | $49.99 | — | — |
| Paramount Peptides | 10 mg | $80.00 | — | — |
| Peptide Crafters | 5 mg | $30.00 | — | — |
| Peptide Crafters | 5 mg | $55.00 | — | — |
| Peptide Crafters | 10 mg | $55.00 | — | — |
| Peptira | — | $69.00 | — | — |
| Pepvida Labs | 13 mg | $79.00 | — | — |
| Polaris Peptides | 10 mg | $75.00 | — | — |
| S1 Research | 5 mg | $40.00 | — | — |
| S1 Research | 10 mg | $40.00 | — | — |
| Solution Peptides | 10 mg | $74.00 | — | — |
| Solution Peptides | 10 mg | $64.00 | — | — |
| Soma Peptides | 10 mg | $69.00 | — | — |
| Southern Aminos | 10 mg | $74.25 | — | — |
| Welli Labs | — | $54.99 | — | — |
| Wellness Peptides | — | $55.00 | — | — |
Research
Performance-enhancing drugs (PEDs) marketed as "research compounds" include unregulated peptides intended to modulate the growth hormone-insulin-like growth factor-1 (GH-IGF-1) axis.
source →Peptides are short chains of amino acids with a unique pharmacological niche between small-molecule drugs and large proteins. Their use in sports medicine is rapidly expanding, driven by patient demand for accelerated injury recovery and performance enhancement.
source →The pursuit of pharmacological enhancement in sport has evolved from the widespread use of anabolic-androgenic steroids (AAS) to novel agents such as peptides and peptide analogues.
source →Background Anterior cervical osteophytes can compress the esophagus, producing dysphagia. Although common on imaging in older adults, symptomatic osteophytic dysphagia is underdiagnosed, and the role of systemic anabolic factors in osteophyte growth is poorly characterized.
source →Growth hormone-releasing hormone (GHRH) and its synthetic analogs are considered performance-enhancing substances and are therefore prohibited by the World Anti-Doping Agency (WADA).
source →Background Injectable peptides are increasingly promoted for musculoskeletal recovery, tissue repair, and performance enhancements; however, clinical adoption has outpaced high-quality evidence and regulatory consensus.
source →Therapeutic peptides are emerging as promising adjuncts in the management of orthopaedic injuries, grounded in their ability to modulate molecular signaling networks central to cellular medicine.
source →Background Therapeutic peptides are short-chain amino acids that regulate cellular functions and facilitate biochemical processes. In recent years, there has been significant growth in the global market for therapeutic peptides and thus its popularity among patients.
source →Therapeutic peptides are short chains of amino acids used to treat metabolic and endocrine conditions such as obesity and type 2 diabetes.
source →GHRH antagonists (GHRHAnt) were developed to suppress cancers and have been associated with robust anti-inflammatory and anti-oxidative activities. The mechanisms involved in those effects are not completely understood.
source →The goal of this clinical trial is to evaluate a long Clomid protocol as compared to a 5-day Clomid protocol for ovarian stimulation in patients with diminished ovarian reserve undergoing ovarian stimulation for in-vitro fertilization.
source →The use of growth hormone-releasing hormones (GHRHs) is prohibited in sports according to the regulations of the World Anti-Doping Agency (WADA). Considering the complexity of urine samples and the low concentrations at which these analytes should be detected, analyzing GHRHs is a challenging task.
source →Matrix effect and sample pretreatment significantly affect the percentage recovery of peptides in biological matrices, affecting the method robustness and accuracy. To counteract this effect, an internal standard (IS) is used; however, in most cases this is not available, which limits the analytical method.
source →In this study, the investigators will examine the effect of therapy with the Growth Hormone Releasing Hormone (GHRH) analog tesamorelin on body composition in patients with HIV lipodystrophy and central adiposity. This study is a single arm prospective study of tesamorelin therapy of patients with HIV lipodystrophy.
source →The aim of this study is to assess the developmental patterns of lung function in children affected by growth hormone deficiency after one year of GH therapy.The assessment by specific questionnaires of quality of life and of parental stress index.Parameters will be evaluated at the time of the diagnosis and after 12 m…
source →The purpose of this study is to assess the safety,tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of an extended dosing regimen of ITF2984: part A, designed as double-blind, placebo-controlled, randomized, tested an extended dosing regimen, i.e. 14 consecutive dosing days and higher doses, i.e.
source →The purpose of this study is to examine the short-term effects of two different doses of growth hormone, compared to treatment with growth hormone releasing hormone, on the brain's secretion of growth hormone and the body's glucose metabolism.
source →Assessing the Efficacy and Long-Term Safety of a 2 mg dose of TH9507, a Growth Hormone-Releasing Factor Analog, in HIV Subjects with Excess Abdominal Fat Accumulation
source →The purpose of this study was to determine whether TH9507, a stabilized analogue of growth hormone-releasing factor (GRF), would have an effect on insulin sensitivity or control of diabetes in patients with type 2 diabetes.
source →The purpose of this study was to validate the growth hormone releasing hormone (GHRH) plus arginine (GHRH+arg) stimulation test and it´s cut-off limits for diagnosis of adult growth hormone deficiency using the growth hormone (GH) Immulite 2000 Xpi assay calibrated against the IS 98/574 from the World Health Organizati…
source →