AOD-9604
aka Anti-Obesity Drug 9604
Mechanism
AOD-9604 is a 16-amino-acid synthetic peptide corresponding to the C-terminal fragment of human growth hormone (residues 177-191) with an additional N-terminal tyrosine. Developed by Metabolic Pharmaceuticals (Australia) to isolate a purported 'lipolytic' activity of GH without GH-receptor-mediated growth or diabetogenic effects. AOD-9604 is NOT FDA-approved for any indication; controlled human trials for obesity did not demonstrate clinically meaningful weight loss, and obesity development was terminated in 2007.
Identification
| CAS number | 221231-10-3 |
|---|---|
| Molecular formula | C78H123N23O23S2 |
| Sequence | YLRIVQCRSVEGSCGF |
| Typical dose | 250–500 mcg/day subcutaneous (research use) |
| Half-life | ~2–3 hours (human); ~3–4 minutes (rat IV, per pharmacokinetic studies) |
Vendors selling AOD-9604
| Vendor | Size | Price | Listed purity | Trust |
|---|---|---|---|---|
| Glacier Aminos | 10 mg | $92.99 | — | 99 |
| Moglabs | 5 mg | $34.00 | — | 96 |
| Moglabs | 5 mg | $36.00 | — | 96 |
| Crush Research | 5 mg | $49.67 | — | 95 |
| Orbitrex Peptides | 5 mg | $54.99 | — | 95 |
| Profound Aminos | 5 mg | $49.00 | — | 95 |
| Prime Peptides | 5 mg | $50.00 | — | 95 |
| Peptide Tech | 5 mg | $42.99 | — | 94 |
| Mile High Compounds | — | $59.99 | — | 94 |
| Amino Club | — | $49.99 | — | 93 |
| Riptide Wellness | — | $45.99 | — | 92 |
| Hydro Research Peptides | 5 mg | $3.50 | — | 91 |
| Hydro Research Peptides | 5 mg | $0.40 | — | 91 |
| Skye Peptides | 6 mg | $59.00 | — | 90 |
| Peptidology | 5 mg | $44.99 | — | 89 |
| Peptidology | 7 mg | $44.99 | — | 89 |
| Peptidology | 10 mg | $44.99 | — | 89 |
| Peptide Plugs | 5 mg | $50.00 | — | 89 |
| Qihang Peptide | — | — | — | 87 |
| Verified Peptides | 5 mg | $49.00 | — | 86 |
| EZ Peptides | 5 mg | $53.00 | — | 85 |
| EZ Peptides | 2 mg | $38.00 | — | 85 |
| Simple Peptide | 10 mg | $80.00 | — | 85 |
| Simple Peptide | 5 mg | $45.00 | — | 85 |
| Peptidegurus | 2 mg | — | — | 84 |
| Peptidegurus | 6 mg | — | — | 84 |
| Ascension Peptides | 5 mg | $55.00 | — | 84 |
| Reta Peptide | — | — | — | 83 |
| Cocer Peptides | 5 mg | $140.00 | — | 82 |
| Cocer Peptides | 5 mg | $140.00 | — | 82 |
| Blank Peptides | 5 mg | $65.00 | — | 81 |
| OROS Research | — | — | — | 79 |
| Texpeptide | 5 mg | $45.00 | — | 70 |
| Crystal Peptides | 5 mg | $49.95 | — | 66 |
| Qing Li Peptide | — | — | — | 63 |
| Certified Peptides | 5 mg | $60.00 | — | 62 |
| Nox Amino | 5 mg | $65.00 | — | 55 |
| Peptiatlas | — | — | — | 51 |
| Taishijie | — | — | — | 51 |
| Taikangbio | — | — | — | 50 |
| MEI-PEPETIDE | 2 mg | $51.00 | — | 48 |
| DongCheng Peptide | — | — | — | 46 |
| Mandy | 5 mg | $74.00 | — | 43 |
| HongDa Peptide | — | $57.00 | — | 43 |
| zztai Peptide Ltd | — | — | — | 43 |
| MJT peptides | 2 mg | $57.00 | — | 39 |
| Cernum Biosciences | 2 mg | $39.99 | — | — |
| Cernum Biosciences | 5 mg | $39.99 | — | — |
| Cernum Biosciences | 10 mg | $79.99 | — | — |
| NG Peptide | 5 mg | $35.00 | — | — |
| Alpha Omega | 5 mg | $45.00 | — | — |
| Arcane Peptides | 5 mg | $40.00 | — | — |
| Atomik Labz | 5 mg | $39.00 | — | — |
| Biotech Peptides | 5 mg | $44.00 | — | — |
| Core Peptides | 5 mg | $41.00 | — | — |
| Felix Chemical Supply | 5 mg | $59.99 | — | — |
| Flawless Compounds | — | — | — | — |
| Kimera Chems | — | $46.99 | — | — |
| Lumi Peptides | — | $40.00 | — | — |
| Nextech Labs | 5 mg | $40.00 | — | — |
| Nova Peptides | 5 mg | $49.99 | — | — |
| Oasis Labs | 5 mg | $54.50 | — | — |
| Oneday Compounds | 5 mg | $54.99 | — | — |
| Paramount Peptides | 6 mg | $75.00 | — | — |
| Peptide Crafters | 10 mg | $80.00 | — | — |
| Peptira | — | $49.00 | — | — |
| Pepvida Labs | 5 mg | $39.00 | — | — |
| Polaris Peptides | 2 mg | $40.00 | — | — |
| Solution Peptides | 5 mg | $39.00 | — | — |
| Soma Peptides | 10 mg | $89.00 | — | — |
| Southern Aminos | 5 mg | $44.25 | — | — |
| True Peptide | 5 mg | $35.00 | — | — |
| Welli Labs | — | $39.99 | — | — |
Research
Peptides are short chains of amino acids with a unique pharmacological niche between small-molecule drugs and large proteins. Their use in sports medicine is rapidly expanding, driven by patient demand for accelerated injury recovery and performance enhancement.
source →Therapeutic peptides are emerging as promising adjuncts in the management of orthopaedic injuries, grounded in their ability to modulate molecular signaling networks central to cellular medicine.
source →Alongside the considerable advances and accomplishments in drug research and development, the breadth of anti-doping research topics has also continued to grow.
source →Background The term post-cycle therapy (PCT) often appears in bodybuilding forums in the context of anabolic-androgenic steroids (AAS) cessation. To reduce the negative impact of AAS on the hormonal system, unapproved PCT is used, which consist of medications that help restore hormonal balance.
source →Since the installation of anti-doping rules and regulations and their international enforcement in the mid-1960s, mass spectrometry has been an integral part of doping control procedures.
source →The analysis of low-molecular-mass peptides in doping controls has become a mandatory aspect in sports drug testing and, thus, the number of samples that has to be tested for these analytes has been steadily increasing.
source →Background To investigate the effects of AOD9604 intra-articular injections with or without hyaluronic acid (HA) in a collagenase-induced knee osteoarthritis (OA) rabbit model. Design Mature New Zealand white rabbits (n=32) were randomly administered 2 mg collagenase type II twice in each knee joint.
source →AOD9604 is a peptide consisting of the C-terminal fragment of human growth hormone from amino acids 177-191 with an additional tyrosine residue at the N-terminus of the peptide. It is reported to mimic the lipolytic properties of growth hormone without the diabetogenic side effects.
source →With the growing availability of mature systems and strategies in biotechnology and the continuously expanding knowledge of cellular processes and involved biomolecules, human sports drug testing has become a considerably complex field in the arena of analytical chemistry.
source →Metabolic is developing AOD-9604 for the potential treatment of obesity. By February 2002, phase IIa trials were underway.
source →Obese-mouse study: AOD-9604 (a GH fragment) increased fat oxidation and weight loss. Note: AOD-9604's subsequent human obesity trials did not demonstrate significant weight loss.
source →Mechanistic study of the synthetic lipolytic domain of human growth hormone (AOD-9604). Biochemical/in-vitro; no demonstrated human efficacy.
source →