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Numerous adverse effects caused by oxidative stress are commonly observed in preterm infants. This stress is caused by the oxidative burden resulting mainly from supplemental oxygen and parenteral nutrition (PN), and by their precarious antioxidant defense.

Neuroendocrine stressors can disrupt the brain's redox equilibrium by generating high levels of reactive oxygen species (ROS) that lead to oxidative stress. To what extent the relationship between neuroendocrine and oxidative stress is modulated by stress coping styles remain unclear.

Cognitive impairment is a core feature of schizophrenia, yet the biological basis has not been established. Redox dysregulation has been implicated in cognitive impairment of patients with schizophrenia but evidence in early-stage, drug-naïve patients is limited and inconsistent.

Background Glutathione is a tripeptide involved in antioxidant defense; however, its systemic availability following oral administration remains controversial, and pharmacokinetic differences between formulations in humans are not well characterized.

Lead exposure remains a pervasive environmental and public health threat, imposing a substantial burden of neurodevelopmental and cognitive dysfunction, yet safe mechanism-oriented interventions remain limited.

Background and aims Oxidative damage caused by drought stress is a key factor limiting crop survival and distribution. The desert plant Pugionium dolabratum exhibits extreme drought tolerance, but its intrinsic antioxidant regulatory mechanism remains unclear.

Growth responses and tolerance of Pistia stratiotes to cadmium (Cd) pollution are not well characterized. We examined P. stratiotes responses to Cd exposure (0, 10, 25, 50, 75, and 100 μM) for 18 days in a hydroponic system.

With the aim of increasing the cysteine-selective bioconjugation reactivity of 4-vinylpyridines, a series of 4-(α-arylvinyl)pyridines were synthesised by Suzuki-Miyaura cross-coupling of 4-(α-bromovinyl)pyridine.

Glutathione S-transferases (GSTs) constitute a critical enzyme superfamily responsible for xenobiotic detoxification in insects.

Background Platinum-based chemotherapy is the frontline treatment for high-grade serous ovarian cancer (HGSOC); however, the development of therapy resistance greatly limits clinical response.

Reactive oxygen species (ROS) burst represents a primary innate immune mechanism of aquatic animals to eliminate invading pathogens. Glutathione (GSH) is a key molecule in mitigating oxidative stress, yet how bacterial pathogens coordinate its synthesis and import remains unclear.

Glutathione (GSH), the most abundant intracellular antioxidant, plays a central role in maintaining redox homeostasis, regulating immune responses, and protecting cellular integrity.

This is a 12-week open-label extension study for participants completing study NCT06221852.

The study is a randomized, double-blind, placebo-controlled, multi-center clinical trial (RCT) with open-label extension study (OLE), of SPI-1005 in adult subjects with definite Meniere's disease with active symptoms within three months preceding study enrollment.

Autism spectrum disorder (ASD) is a lifelong developmental disability that includes deficits in social communication and social interaction and restricted, repetitive patterns of behavior, interests, or activities.

In this study, the investigators will stratify depressed subjects a priori based on CRP levels to test the hypothesis that eicosapentaenoic (EPA) would be more efficacious to treat depression in subjects with high CRP levels compared to subjects with low CRP levels.

The effect oral iron chelator Deferiprone on the Oxidative stress and on Iron Overload status in transfusion dependent, iron-overloaded low risk MDS patients; Primary Objective: • To evaluate the effect of Deferiprone on oxidative stress parameter - Reactive oxygen species (ROS).

The purpose of this study is to measure levels of blood and brain chemicals related to oxidative stress and inflammation in healthy volunteers and individuals with Type 1 Gaucher disease (GD1) to see if these levels are altered by GD1.

The treatment of breast cancer at any given time can be through surgery, as well as adjuvant treatments (radiotherapy, chemotherapy and hormone therapy) alone or together. And with this the patient tends to lose weight, he becomes depressed, resulting in an increasingly debilitating picture.

Nuclear factor kappa B (NF-κB) pathway and oxidative stress participate in endothelial dysfunction, which is one of the causes of preeclampsia. Among the human antioxidant mechanisms there are the enzymes catalase (CAT), glutathione peroxidase (GPx) and superoxide dismutase (SOD).