GHK-Cu
aka Glycyl-L-histidyl-L-lysine Copper
Mechanism
GHK-Cu is the copper(II) complex of a human tripeptide found in plasma. It is a well-established topical cosmetic ingredient for photoaged skin and is NOT an FDA-approved drug.
Identification
| CAS number | 89030-95-5 |
|---|---|
| Molecular formula | C14H22CuN6O4 |
| Sequence | GHK |
| Typical dose | 1–2 mg/day subcutaneous (research use) |
| Half-life | ~30 minutes (plasma); tissue-bound activity reported 24–72 hours |
Vendors selling GHK-Cu
| Vendor | Size | Price | Listed purity | Trust |
|---|---|---|---|---|
| Peptide Partners | 200 mg | $150.00 | — | 99 |
| Glacier Aminos | 50 mg | $41.99 | — | 99 |
| Glacier Aminos | 100 mg | $41.99 | — | 99 |
| Moglabs | 50 mg | $30.00 | — | 96 |
| Crush Research | 100 mg | $99.00 | — | 95 |
| Orbitrex Peptides | 50 mg | $39.99 | — | 95 |
| Profound Aminos | 50 mg | $49.00 | — | 95 |
| Reta One Labs | 100 mg | $49.00 | — | 95 |
| Reta One Labs | 50 mg | $29.00 | — | 95 |
| Licensed Peptides | 50 mg | $61.99 | — | 95 |
| Licensed Peptides | 100 mg | $61.99 | — | 95 |
| Prime Peptides | 100 mg | $65.00 | — | 95 |
| Peptide Tech | — | $38.99 | — | 94 |
| Mile High Compounds | — | $49.99 | — | 94 |
| Mile High Compounds | — | $119.99 | — | 94 |
| Forge Performance Co. | 100 mg | $50.00 | — | 94 |
| Amino Club | 50 mg | $29.99 | — | 93 |
| Riptide Wellness | — | $49.99 | — | 92 |
| Hydro Research Peptides | 100 mg | $0.45 | — | 91 |
| Skye Peptides | 50 mg | $49.00 | — | 90 |
| Peptidology | 2.56 mg | $114.99 | — | 89 |
| Peptide Plugs | 100 mg | $40.00 | — | 89 |
| Sunrise Bioresearch | 50 mg | $23.72 | — | 88 |
| Qihang Peptide | — | — | — | 87 |
| Simple Peptide | 100 mg | $55.00 | — | 85 |
| Peptidegurus | 50 mg | — | — | 84 |
| Reta Peptide | — | — | — | 83 |
| Cocer Peptides | 50 mg | $55.00 | — | 82 |
| Cocer Peptides | 100 mg | $80.00 | — | 82 |
| Blank Peptides | 100 mg | $75.00 | — | 81 |
| OROS Research | 50 mg | — | — | 79 |
| Crystal Peptides | 50 mg | $29.99 | — | 66 |
| Crystal Peptides | 100 mg | $44.99 | — | 66 |
| Qing Li Peptide | — | — | — | 63 |
| Certified Peptides | 100 mg | $59.00 | — | 62 |
| Nox Amino | 50 mg | $45.00 | — | 55 |
| Peptiatlas | 100 mg | — | — | 51 |
| Peptiatlas | — | — | — | 51 |
| Taishijie | — | — | — | 51 |
| Taikangbio | — | — | — | 50 |
| Zjpeptix | — | — | — | 50 |
| Hkuppeptide | 50 mg | $10.00 | — | 50 |
| Hkuppeptide | 100 mg | $10.00 | — | 50 |
| MEI-PEPETIDE | 50 mg | $32.00 | — | 48 |
| DongCheng Peptide | — | — | — | 46 |
| Mandy | 50 mg | $18.00 | — | 43 |
| HongDa Peptide | — | $34.00 | — | 43 |
| zztai Peptide Ltd | — | — | — | 43 |
| MJT peptides | 50 mg | $30.00 | — | 39 |
| HK Peptide Ltd (hk peptides) | — | — | — | 37 |
| Alpha Peptides | — | — | — | — |
| Apollo Peptide Sciences | — | $119.99 | — | — |
| Cernum Biosciences | 50 mg | $39.99 | — | — |
| Cernum Biosciences | 100 mg | $59.99 | — | — |
| NG Peptide | 50 mg | $20.00 | — | — |
| Ruo Bio | 50 mg | $28.00 | — | — |
| Alpha Omega | 100 mg | $55.00 | — | — |
| Amino Sequence | 100 mg | $55.00 | — | — |
| Arcane Peptides | — | $35.00 | — | — |
| Felix Chemical Supply | 50 mg | $54.99 | — | — |
| Felix Chemical Supply | 100 mg | $59.99 | — | — |
| Flawless Compounds | — | — | — | — |
| Ignite Peptides | 100 mg | $60.00 | — | — |
| Kimera Chems | 50 mg | $36.99 | — | — |
| Lumi Peptides | — | $40.00 | — | — |
| Modern Research Peptides | 100 mg | $37.49 | — | — |
| Nova Peptides | 50 mg | $39.99 | — | — |
| Nova Peptides | 100 mg | $39.99 | — | — |
| Oasis Labs | 50 mg | $38.50 | — | — |
| Oasis Labs | 100 mg | $38.50 | — | — |
| Oneday Compounds | 50 mg | $54.99 | — | — |
| Peptira | 50 mg | $39.00 | — | — |
| Peptira | 100 mg | $59.00 | — | — |
| Platinum Lion | 100 mg | $39.99 | — | — |
| Platinum Lion | 50 mg | $39.99 | — | — |
| Polaris Peptides | 50 mg | $35.00 | — | — |
| Puratek Peptides | — | $28.95 | — | — |
| S1 Research | 100 mg | $28.00 | — | — |
| Soma Peptides | 50 mg | $59.00 | — | — |
| Soma Peptides | 100 mg | $59.00 | — | — |
| Southern Aminos | 100 mg | $36.75 | — | — |
| True Peptide | 100 mg | $45.00 | — | — |
| True Peptide | 50 mg | $45.00 | — | — |
| Welli Labs | — | $26.99 | — | — |
| Welli Labs | — | $34.99 | — | — |
| Wellness Peptides | — | $35.00 | — | — |
Research
The goal of this clinical trial is to investigate GHK and GHK-Cu blood levels pre- and post-intervention in healthy adults, and to investigate the efficacy of X39 patch on GHK and GHK-Cu blood levels in healthy adults compared to a placebo.
source →Laccase plays an important role in the detection and degradation of phenolic compounds, but it is limited by its cost and stability. In this study, the laccase-like property of copper peptide (GHK-Cu) has been revealed.
source →Aging is a complex biological process characterized by progressive functional decline across tissues and increased susceptibility to age-related diseases, with oxidative stress being a key contributing factor.
source →Inflammation serves as a basic defense mechanism against both internal and external threats, while the unresolved or excessive inflammation can lead to irreversible tissue damage.
source →This study will evaluate whether a topical gel containing GHK-Cu (a copper(II)-peptide complex) can safely speed up healing of small, standardized skin wounds in healthy adults compared with a matching vehicle gel.
source →Introduction Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) characterized by mucosal damage and impaired epithelial barrier function. While glycyl-l-histidyl-l-lysine-copper (GHK-Cu) exhibits known anti-inflammatory properties, its therapeutic mechanisms in UC remain undefined.
source →With the wide application of soft tissue fillers, implant material-induced inflammatory reactions have become a key factor affecting the therapeutic efficacy.
source →Cosmetically active compounds (CACs), both of lipophilic and hydrophilic origin, have difficulty reaching the deeper layers of the skin, and this shortcoming significantly reduces their efficacy.
source →The hyphenation of the separation technique with the high-sensitive mass spectrometry detection is one of the driving forces of modern analysis enabling measurements in complex matrices.
source →Liposomes are self-assembled spherical systems composed of amphiphilic phospholipids. They can be used as carriers of both hydrophobic and hydrophilic substances, such as the anti-aging and wound-healing copper-binding peptide, GHK-Cu (glycyl-L-histidyl-L-lysine).
source →Sensing important metals in different environments is an important area and involves the development of a wide variety of metal-sensing materials. The employment of fluorescent sensors in metal sensing has been one of the most widely applied methodologies, and the identification of selective metal sensors is important.
source →Introduction GHK-Cu and HA are two commonly used skin care ingredients, both of which were reported to enhance collagen synthesis. This work aims to investigate their co-effect on collagen regulation.
source →This is a phase IV, unblinded, open-label study assessing the impact on skin quality, hydration, and barrier of three (3) Hydrafacial treatments in healthy adults of Fitzpatrick Skin Types I \& II, III, IV, V \& VI, 30 to 55 years of age.
source →The crystallinity of a nonfullerene small-molecule acceptor plays an important function in the bimolecular recombination and carrier transfer of polymer solar cells (PSCs).
source →