peptide wiki

Selank

aka Selank (TP-7)

Nootropic / Cognitive

Mechanism

Selank is a synthetic heptapeptide analog of the immunomodulatory tetrapeptide tuftsin. It is registered as a prescription anxiolytic in Russia (0.15% intranasal solution); it is not FDA or EMA approved.

Identification

CAS number129954-34-3
Molecular formulaC33H57N11O9
SequenceTKPRPGP
Typical dose250–500 mcg/day subcutaneous (research); 600–2700 mcg/day intranasal (Russian clinical protocols)
Half-life~2–3 minutes (plasma); downstream effects persist hours to days

Vendors selling Selank

VendorSizePriceListed purityTrust
Peptide Partners 60 mg $234.00 99
Glacier Aminos 10 mg $40.99 99
Moglabs 5 mg $24.00 96
Moglabs 5 mg $36.00 96
Crush Research 5 mg 95
Orbitrex Peptides 10 mg $29.99 95
Profound Aminos 10 mg $39.00 95
Ion Peptide 10 mg $49.00 95
Ion Peptide $25.00 95
Licensed Peptides 40 mg $129.99 95
Licensed Peptides 10 mg $61.99 95
Prime Peptides 20 mg $90.00 95
Peptide Tech 5 mg $23.99 94
Mile High Compounds $39.99 94
Amino Club $29.99 93
Riptide Wellness $47.99 92
Hydro Research Peptides 5 mg $0.35 91
Skye Peptides 5 mg $49.00 90
Peptidology 10 mg $41.00 89
Peptide Plugs 20 mg $60.00 89
Peptide Plugs 10 mg $40.00 89
Sunrise Bioresearch 50 mg $132.20 88
Sunrise Bioresearch 10 mg $26.98 88
Qihang Peptide 87
EZ Peptides 10 mg $44.00 85
Simple Peptide 10 mg $55.00 85
Peptidegurus 10 mg 84
Peptidegurus 10 mg 84
Ascension Peptides 10 mg $47.50 84
Cocer Peptides 10 mg $60.00 82
Cocer Peptides 10 mg $60.00 82
Cocer Peptides 50 mg $320.00 82
Blank Peptides 10 mg $50.00 81
OROS Research 10 mg 79
Texpeptide 10 mg $35.00 70
Crystal Peptides 5 mg $24.99 66
Crystal Peptides 10 mg $49.99 66
Qing Li Peptide 63
Certified Peptides 10 mg $50.00 62
Nox Amino 10 mg $49.00 55
Peptiatlas 51
Taishijie 51
Taikangbio 50
DongCheng Peptide 46
Mandy 5 mg $33.00 43
HongDa Peptide $57.00 43
zztai Peptide Ltd 43
MJT peptides 5 mg $46.00 39
Cernum Biosciences 5 mg $46.99
Cernum Biosciences 10 mg $86.99
NG Peptide 10 mg $30.00
Strate Labs $59.95
AMC Essentials 10 mg $39.99
AMC Essentials 10 mg $49.99
Alpha Omega 10 mg $55.00
Arcane Peptides 5 mg $30.00
Atomik Labz 10 mg $46.00
Atomik Labz 10 mg $35.00
Biotech Peptides 10 mg $46.00
Bulk Peptides 5 mg $140.00
Core Peptides 10 mg $52.00
Felix Chemical Supply 10 mg $34.99
Flawless Compounds
Flawless Compounds
Flawless Compounds 40 mg
Genetic Peptide 10 mg $55.00
Genetic Peptide 30 mg $55.00
Ignite Peptides 10 mg $30.00
Kimera Chems $26.99
Lumi Peptides $35.00
Modern Research Peptides 10 mg $31.29
Nextech Labs 10 mg $49.00
Nextech Labs 10 mg $49.50
Nova Peptides 10 mg $44.99
Oasis Labs 10 mg $96.50
Oasis Labs 10 mg $52.50
Oneday Compounds 10 mg $44.99
Paramount Peptides 5 mg $33.00
Paramount Peptides 10 mg $49.00
Peptide Crafters 10 mg $35.00
Peptide Crafters 10 mg $45.00
Peptira $49.00
Pepvida Labs 10 mg $29.98
Platinum Lion 5 mg $49.99
Puratek Peptides 10 mg $32.95
Solution Peptides 10 mg $46.00
Solution Peptides 10 mg $35.00
Soma Peptides $129.00
Soma Peptides 10 mg $49.00
Southern Aminos 10 mg $48.75
Welli Labs $29.99
Wellness Peptides $35.00

Research

Therapeutic Peptides in Aesthetic, Metabolic and Endocrine Conditions: Effects, Safety, Clinical Applications, and Future Perspectives
Renke G, Chinellato L. · International journal of molecular sciences (2026) · review

Therapeutic peptides are short chains of amino acids used to treat metabolic and endocrine conditions such as obesity and type 2 diabetes.

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Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions
Rahman OF, Lee SJ, Seeds WA. · Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews (2026) · review

Therapeutic peptides are emerging as promising adjuncts in the management of orthopaedic injuries, grounded in their ability to modulate molecular signaling networks central to cellular medicine.

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Phenibutan—an Illegal Food Supplement With Psychotropic Effects and Health Risks
Bonnet U, Scherbaum N, Schaper A, Soyka M. · Deutsches Arzteblatt international (2024) · review

Background Phenibut (β-phenyl-γ-aminobutyric acid) is an analog of the neurotransmitter gamma-aminobutyric acid (GABA). Like abapentin and pregabalin, it inhibits α2-δ-subunits of voltagedependent presynaptic calcium channels.

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Comparing the Efficacy of tDCS and tRNS to Improve Reading Skills in Children and Adolescents With Dyslexia
· ClinicalTrials.gov (2023) · rct

The present study grounds on the absence of evidence-based treatment in individuals with developmental dyslexia (DD).

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The Effect of Balance Exercises on Cognitive Function
· ClinicalTrials.gov (2023) · rct

The aim of our study is to examine the effects of balance exercises performed in virtual and real environments on visual-spatial attention and mental rotation in healthy young adult individuals using EEG brain oscillations.

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Selank, a Peptide Analog of Tuftsin, Attenuates Aversive Signs of Morphine Withdrawal in Rats
Konstantinopolsky MA, Chernyakova IV, Kolik LG. · Bulletin of experimental biology and medicine (2022) · animal

Activity of a peptide tuftsin analogue Selank was studied in outbred rats using the naloxone-precipitated morphine withdrawal model.

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The Study on Effects of Acute Exposure to High Altitude Hypoxia on Cognitive Function in Lowlanders
· ClinicalTrials.gov (2022) · cohort

The purpose of this study is to investigate the impact of rapid elevation to 3,800 meters on the cognitive function of low-altitude residents through a plateau field and plain control study, and explore the objective indicators related to the impaired cognitive function.

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Neural Mechanisms and Efficacy of Imagery Rescripting for Fear of Failure
· ClinicalTrials.gov (2022) · rct

This randomized controlled trial investigates the neural and psychophysiological mechanisms of Imagery Rescripting (ImRs) in individuals with high fear of failure. Participants (N=81, aged 21-34) were randomized to ImRs or an active control condition.

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Sedative-Hypnotic Agents That Impact Gamma-Aminobutyric Acid Receptors: Focus on Flunitrazepam, Gamma-Hydroxybutyric Acid, Phenibut, and Selank
Doyno CR, White CM. · Journal of clinical pharmacology (2021) ·

There are many nonopioid central nervous system depressant substances that share a gamma-aminobutyric acid (GABA) receptor-related mechanism of action.

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The Influence of Selank on the Level of Cytokines Under the Conditions of "Social" Stress
Leonidovna YA, Aleksandrovna SM, Aleksandrovna TA, Aleksandrovna BO, Fedorovich MN, Aleksandrovna AL. · Current reviews in clinical and experimental pharmacology (2021) · animal

Background It was previously thought that inflammation and an immune response were the only factors capable of causing IL-1β, IL-6 and other cytokine`s production.

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Neurofeedback Training for Dyslexia
· ClinicalTrials.gov (2021) · rct

The study aims at testing a Neurofeedback (NF) training specifically designed for inducing a functional hemispheric imbalance of the tempo-parietal regions in individuals with dyslexia.

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Morphological Changes in the Large Intestine of Rats Subjected to Chronic Restraint Stress and Treated with Selank
Mukhina AY, Mishina ES, Bobyntsev II, Medvedeva OA, Svishcheva MV, Kalutskii PV, Andreeva LA, Myasoedov NF. · Bulletin of experimental biology and medicine (2020) · animal

We studied the effects of Selank on the condition of the colon wall in Wistar male rats subjected to restraint stress. Selank was injected intraperitoneally in doses of 80, 250, and 750 μg/kg 15 min before stress exposure.

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Functional Connectomic Approach to Studying Selank and Semax Effects
Panikratova YR, Lebedeva IS, Sokolov OY, Rumshiskaya AD, Kupriyanov DA, Kost NV, Myasoedov NF. · Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections (2020) ·

The present study was aimed at the assessment of effects of anxiolytic Selank and nootropic Semax on the whole-brain resting-state functional connectivity (FC) of each of the predefined regions of interest (ROIs) in 52 healthy participants.

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Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats
Kolik LG, Nadorova AV, Antipova TA, Kruglov SV, Kudrin VS, Durnev AD. · Bulletin of experimental biology and medicine (2019) · animal

The effects of a peptide anxiolytic Selank synthesized on the basis of the endogenous peptide tuftsin on memory impairment and content of brain-derived neurotrophic factor (BDNF) in brain structures were analyzed in outbred rats receiving 10% ethanol as the only source of fluid for 30 weeks.

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Effect of Selank on Morphological Parameters of Rat Liver in Chronic Foot-Shock Stress
Fomenko EV, Bobyntsev II, Ivanov AV, Belykh AE, Andreeva LA, Myasoedov NF. · Bulletin of experimental biology and medicine (2019) · animal

We studied the effects of Selank on morphological parameters of the liver in Wistar male rats subjected to chronic foot-shock stress. Selank was injected intraperitoneally in doses of 100, 300 and 1000 μg/kg 15 min before each stress session.

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State of Colon Microbiota in Rats during Chronic Restraint Stress and Selank Treatment
Mukhina AY, Medvedeva OA, Svishcheva MV, Shevchenko AV, Efremova NN, Bobyntsev II, Kalutskii PV, Andreeva LA, Myasoedov NF. · Bulletin of experimental biology and medicine (2019) · animal

We studied the effects of Selank on intestinal microbiota in Wistar male rats subjected to chronic restraint stress. Selank was injected intraperitoneally in doses of 80, 250 and 750 μg/kg 15 min before stress exposure.

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Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity
Vyunova TV, Andreeva L, Shevchenko K, Myasoedov N. · Protein and peptide letters (2018) · animal

Background Anxiety and mood disorders are the most abundant mental health problems worldwide. The commonly used in clinical practice anxiolytics are focused on pharmacological modulation of brain GABA receptor system activity.

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Trial of Telephone-based Psychotherapy for Depression With and Without Adjunctive Supportive Mail
· ClinicalTrials.gov (2012) · rct

This study aims to compare the effectiveness of two telephone-based psychotherapy (Tel-PT) interventions for patients with mild to moderate depression.

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Double-blind, Randomized Study Evaluating the Efficacy and Safety of Brivaracetam in Adults With Partial Onset Seizures
· ClinicalTrials.gov (2007) · rct

This study will evaluate the efficacy and safety of Brivaracetam to support the submission file in the indication of adjunctive treatment in adolescents and adults with partial onset seizures.

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Brivaracetam as add-on Treatment in Adolescents and Adults Suffering From Epilepsy
· ClinicalTrials.gov (2007) · rct

This study will compare the safety and efficacy of Brivaracetam at flexible dose with Placebo in subjects suffering from Epilepsy.

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