PT-141
aka Bremelanotide
Mechanism
PT-141 (Bremelanotide) is a cyclic heptapeptide melanocortin receptor agonist derived from Melanotan II. It is FDA-approved as Vyleesi (2019) for hypoactive sexual desire disorder in premenopausal women only.
Identification
| CAS number | 189691-06-3 |
|---|---|
| Molecular formula | C50H68N14O10 |
| Typical dose | 0.5–2 mg subcutaneous, administered ~45 minutes before activity; FDA-approved dose is 1.75 mg SC (max one dose per 24h, ≤8 doses/month) |
| Half-life | ~2.7 hours (range 1.9–4.0 hours) |
Vendors selling PT-141
| Vendor | Size | Price | Listed purity | Trust |
|---|---|---|---|---|
| Peptide Partners | 10 mg | $84.00 | — | 99 |
| Glacier Aminos | 10 mg | $40.99 | — | 99 |
| Moglabs | 10 mg | $36.00 | — | 96 |
| BioLongevity Labs | — | $199.97 | — | 96 |
| BioLongevity Labs | 5 mg | $47.97 | — | 96 |
| Crush Research | 10 mg | $99.00 | — | 95 |
| Orbitrex Peptides | — | $49.99 | — | 95 |
| Profound Aminos | 10 mg | $59.00 | — | 95 |
| Reta One Labs | 10 mg | $26.00 | — | 95 |
| Licensed Peptides | 10 mg | $517.45 | — | 95 |
| Licensed Peptides | 30 mg | $159.99 | — | 95 |
| Licensed Peptides | 10 mg | $87.99 | — | 95 |
| Peptide Tech | 10 mg | $33.99 | — | 94 |
| Mile High Compounds | — | $44.99 | — | 94 |
| Amino Club | — | $29.99 | — | 93 |
| Riptide Wellness | — | $44.99 | — | 92 |
| Hydro Research Peptides | 10 mg | $0.50 | — | 91 |
| Skye Peptides | 10 mg | $44.00 | — | 90 |
| Peptidology | 10 mg | $43.00 | — | 89 |
| Peptide Plugs | 10 mg | $40.00 | — | 89 |
| Sunrise Bioresearch | 50 mg | $124.41 | — | 88 |
| Sunrise Bioresearch | 10 mg | $25.39 | — | 88 |
| Qihang Peptide | — | — | — | 87 |
| Verified Peptides | 10 mg | $34.99 | — | 86 |
| EZ Peptides | 10 mg | $44.00 | — | 85 |
| Simple Peptide | 10 mg | $45.00 | — | 85 |
| Peptidegurus | 5 mg | — | — | 84 |
| Peptidegurus | 10 mg | — | — | 84 |
| Peptidegurus | 10 mg | — | — | 84 |
| Peptidegurus | 10 mg | — | — | 84 |
| Peptidegurus | 20 mg | — | — | 84 |
| Peptidegurus | 30 mg | — | — | 84 |
| Ascension Peptides | 10 mg | $49.00 | — | 84 |
| Reta Peptide | — | — | — | 83 |
| Cocer Peptides | 10 mg | $65.00 | — | 82 |
| Blank Peptides | 10 mg | $55.00 | — | 81 |
| OROS Research | 10 mg | — | — | 79 |
| Texpeptide | 10 mg | $40.00 | — | 70 |
| Crystal Peptides | 10 mg | $39.99 | — | 66 |
| Qing Li Peptide | — | — | — | 63 |
| Certified Peptides | 10 mg | $58.00 | — | 62 |
| Nox Amino | 10 mg | $45.00 | — | 55 |
| Peptiatlas | — | — | — | 51 |
| Taishijie | — | — | — | 51 |
| Taikangbio | — | — | — | 50 |
| MEI-PEPETIDE | 10 mg | $68.00 | — | 48 |
| DongCheng Peptide | — | — | — | 46 |
| Mandy | 10 mg | $48.00 | — | 43 |
| HongDa Peptide | — | $71.00 | — | 43 |
| zztai Peptide Ltd | — | — | — | 43 |
| MJT peptides | 10 mg | $59.00 | — | 39 |
| HK Peptide Ltd (hk peptides) | — | — | — | 37 |
| Cernum Biosciences | 10 mg | $44.99 | — | — |
| NG Peptide | 10 mg | $24.99 | — | — |
| AMC Essentials | 10 mg | $36.99 | — | — |
| Alpha Omega | 10 mg | $45.00 | — | — |
| Arcane Peptides | 10 mg | $30.00 | — | — |
| Atomik Labz | 10 mg | $37.00 | — | — |
| Biotech Peptides | 10 mg | $45.00 | — | — |
| Core Peptides | 10 mg | $43.00 | — | — |
| Felix Chemical Supply | 10 mg | $42.99 | — | — |
| Flawless Compounds | — | — | — | — |
| Flawless Compounds | 30 mg | — | — | — |
| Genetic Peptide | — | $99.00 | — | — |
| Genetic Peptide | 10 mg | $55.00 | — | — |
| Ignite Peptides | 10 mg | $30.00 | — | — |
| Kimera Chems | — | $41.99 | — | — |
| Lumi Peptides | — | $35.00 | — | — |
| Modern Research Peptides | 10 mg | $32.99 | — | — |
| Nextech Labs | 10 mg | $49.99 | — | — |
| Nova Peptides | — | $59.99 | — | — |
| Nova Peptides | 10 mg | $39.99 | — | — |
| Oasis Labs | 10 mg | $36.00 | — | — |
| Oneday Compounds | 10 mg | $49.99 | — | — |
| Paramount Peptides | 10 mg | $57.00 | — | — |
| Paramount Peptides | 5 mg | $50.00 | — | — |
| Peptide Crafters | 10 mg | $35.00 | — | — |
| Peptira | — | $49.00 | — | — |
| Pepvida Labs | — | $26.99 | — | — |
| Platinum Lion | — | $39.99 | — | — |
| Polaris Peptides | 10 mg | $40.00 | — | — |
| Polaris Peptides | 15 mg | $50.00 | — | — |
| Puratek Peptides | 10 mg | $31.45 | — | — |
| S1 Research | 10 mg | $35.00 | — | — |
| Solution Peptides | 10 mg | $37.00 | — | — |
| Soma Peptides | 10 mg | $49.00 | — | — |
| Southern Aminos | 10 mg | $44.25 | — | — |
| True Peptide | 10 mg | $36.00 | — | — |
| Welli Labs | — | $29.99 | — | — |
| Wellness Peptides | — | $40.00 | — | — |
Research
Background Hypoactive Sexual Desire Disorder (HSDD) is a prevalent and distressing condition affecting adult women and is associated with significant impairments in quality of life and interpersonal relationships.
source →Erectile dysfunction (ED) is a common condition among aging men, often associated with metabolic disorders, diabetes mellitus, hypertension, oligozoospermia, cardiovascular disease, sedentary lifestyles, chronic infections, and inflammation.
source →Therapeutic peptides are short chains of amino acids used to treat metabolic and endocrine conditions such as obesity and type 2 diabetes.
source →Background Peptide therapeutics represent an emerging frontier in gerontological medicine, targeting fundamental hallmarks of aging including metabolic dysfunction, telomere attrition, tissue repair impairment, and hormonal decline.
source →Introduction Erectile dysfunction (ED) pathophysiology involves complex interactions between vasculogenic, hormonal, and neurological mechanisms, with endothelial dysfunction and oxidative stress playing crucial roles.
source →A Phase 3, Randomized, Double-blind, Placebo-controlled, Parallel-group Trial with an optional Open-label Extension to evaluate the efficacy of bremelanotide (BMT), administered subcutaneously (SC) on an as needed basis for the treatment of HSDD (with or without decreased arousal) in premenopausal females.
source →A Phase 3, Randomized, Double-blind, Placebo-controlled, Parallel-group Trial with an optional Open-label Extension to evaluate the efficacy of bremelanotide (BMT), administered subcutaneously (SC) on an as needed basis for the treatment of HSDD (with or without decreased arousal) in premenopausal females.
source →This trial is designed to evaluate the efficacy and safety of 3 fixed dose levels of bremelanotide, administered subcutaneously on an as-needed basis under conditions of home use, for the treatment of female sexual arousal disorder (FSAD), hypoactive sexual desire disorder (HSDD), or mixed FSAD/HSDD in premenopausal wo…
source →This invention relates to a method for preparing cyclic 7-mer phage peptides PT-141 and MT-II.
source →No information is available on the clinical use of bremelanotide during breastfeeding. Because bremelanotide is a cyclic peptide molecule with a molecular weight of 1025, the amount in milk is likely to be very low and absorption is unlikely because it is probably destroyed in the infant's gastrointestinal tract.
source →Introduction Melanocortins affect multiple physiological responses, including sexual behaviors. Bremelanotide is a synthetic peptide melanocortin analog of alpha-melanocyte-stimulating hormone that is an agonist at melanocortin receptors MC3R and MC4R.
source →This 8 week at home study is designed to explore efficacy endpoints and evaluate the safety of intranasal Bremelanotide in women with Female Sexual Arousal Disorder. Efficacy will be assessed vs. a parallel placebo group.
source →Objectives To evaluate the safety and pharmacodynamic effect of co-administration of subtherapeutic doses of PT-141, a cyclic heptapeptide melanocortin analogue, and sildenafil to patients with erectile dysfunction.
source →Palatin, under license from Competitive Technology, is developing the peptide PT-141, a synthetically modified analog of PT-14, as a nasal spray for the potential treatment of erectile dysfunction (ED) and female sexual dysfunction.
source →PT-141, a cyclic heptapeptide melanocortin analog, was evaluated following subcutaneous administration to healthy male subjects and to patients with erectile dysfunction (ED) who report an inadequate response to Viagra.
source →PT-141, a synthetic peptide analogue of alpha-MSH, is an agonist at melanocortin receptors including the MC3R and MC4R, which are expressed primarily in the central nervous system. Administration of PT-141 to rats and nonhuman primates results in penile erections.
source →