PT-141
Melanocortin research-only
Mechanism
No mechanism summary on file.
Identification
| CAS number | 189691-06-3 |
|---|---|
| Molecular formula | C50H68N14O10 |
Safety
Active ingredient (bremelanotide) is FDA-approved as Vyleesi for hypoactive sexual desire disorder in premenopausal women (AMAG Pharmaceuticals, 2019). Research-market PT-141 is not Vyleesi and is not FDA-controlled. Documented side effects include flushing, transient hypertension, nausea, and dose-dependent hyperpigmentation.
Vendors selling PT-141
| Vendor | Size | Price | Listed purity | Trust |
|---|---|---|---|---|
| Nuscience Peptides | — | — | — | 60 |
| Peptide Sciences | — | — | — | 26 |
Research
Intravenous peptides and amino acids for erectile dysfunction: a narrative review of current applications and future directions.
Ila V, Pozzi E, Gamage M, et al. · Expert Opin Pharmacother (2025) · review
source → Melanocortins in the treatment of male and female sexual dysfunction.
Shadiack AM, Sharma SD, Earle DC, et al. · Curr Top Med Chem (2007) · review
source → Bremelanotide.
· (2006) · review
source → Melanocortin peptide therapeutics: historical milestones, clinical studies and commercialization.
Hadley ME, Dorr RT · Peptides (2006) · review
source → Gateways to clinical trials.
Bayes M, Rabasseda X, Prous JR · Methods Find Exp Clin Pharmacol (2005) ·
source → Co-administration of low doses of intranasal PT-141, a melanocortin receptor agonist, and sildenafil to men with erectile dysfunction results in an enhanced erectile response.
Diamond LE, Earle DC, Garcia WD, et al. · Urology (2005) · rct
source → Gateways to clinical trials.
Bayes M, Rabasseda X, Prous JR · Methods Find Exp Clin Pharmacol (2004) ·
source → PT-141 Palatin.
Hedlund P · Curr Opin Investig Drugs (2004) · review
source → Evaluation of the safety, pharmacokinetics and pharmacodynamic effects of subcutaneously administered PT-141, a melanocortin receptor agonist, in healthy male subjects and in patients with an inadequate response to Viagra.
Rosen RC, Diamond LE, Earle DC, et al. · Int J Impot Res (2004) · rct
source → PT-141: a melanocortin agonist for the treatment of sexual dysfunction.
Molinoff PB, Shadiack AM, Earle D, et al. · Ann N Y Acad Sci (2003) · rct
source →