Ipamorelin
aka IPA
Mechanism
Ipamorelin is a synthetic pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH2) originally developed by Novo Nordisk and later advanced by Helsinn/Nycomed. It is a selective ghrelin receptor agonist / growth hormone secretagogue (GHRP). Its defining feature versus older GHRPs (GHRP-2, GHRP-6, hexarelin) is that in preclinical and early clinical studies it raised GH without meaningfully increasing ACTH, cortisol, or prolactin. It is not FDA-approved for any indication; a Phase 2 trial for postoperative ileus failed to meet its primary endpoint and clinical development was discontinued. In the wellness/grey market it is sold as a research chemical and used off-label for anti-aging and body-composition goals despite no clinically validated human dose for those uses.
Identification
| CAS number | 170851-70-4 |
|---|---|
| Molecular formula | C38H49N9O5 |
| Typical dose | 100–300 mcg per injection subcutaneous, typically 1–3x daily in research use |
| Half-life | ~2 hours |
Vendors selling Ipamorelin
| Vendor | Size | Price | Listed purity | Trust |
|---|---|---|---|---|
| Peptide Partners | 20 mg | $82.00 | — | 99 |
| Glacier Aminos | 10 mg | $51.99 | — | 99 |
| Moglabs | 5 mg | $28.00 | — | 96 |
| BioLongevity Labs | 10 mg | $79.97 | — | 96 |
| Crush Research | 10 mg | $129.00 | — | 95 |
| Orbitrex Peptides | 10 mg | $59.99 | — | 95 |
| Profound Aminos | 10 mg | $59.00 | — | 95 |
| Licensed Peptides | 10 mg | $404.95 | — | 95 |
| Licensed Peptides | 5 mg | $43.32 | — | 95 |
| Licensed Peptides | 10 mg | $43.32 | — | 95 |
| Prime Peptides | 10 mg | $55.00 | — | 95 |
| Peptide Tech | — | $33.99 | — | 94 |
| Mile High Compounds | — | $59.99 | — | 94 |
| Amino Club | — | $49.99 | — | 93 |
| Riptide Wellness | — | $49.99 | — | 92 |
| Hydro Research Peptides | 5 mg | $0.30 | — | 91 |
| Skye Peptides | 10 mg | $69.00 | — | 90 |
| Peptidology | 10 mg | $58.00 | — | 89 |
| Peptide Plugs | 10 mg | $30.00 | — | 89 |
| Sunrise Bioresearch | 50 mg | $222.99 | — | 88 |
| Sunrise Bioresearch | 10 mg | $44.69 | — | 88 |
| Qihang Peptide | — | — | — | 87 |
| Verified Peptides | — | $33.00 | — | 86 |
| EZ Peptides | 10 mg | $44.00 | — | 85 |
| Simple Peptide | 10 mg | $65.00 | — | 85 |
| Simple Peptide | — | $65.00 | — | 85 |
| Peptidegurus | 2 mg | — | — | 84 |
| Peptidegurus | 5 mg | — | — | 84 |
| Peptidegurus | 10 mg | — | — | 84 |
| Ascension Peptides | 5 mg | $44.00 | — | 84 |
| Reta Peptide | — | — | — | 83 |
| MedGe Peptides | 10 mg | $80.00 | — | 82 |
| Blank Peptides | 10 mg | $55.00 | — | 81 |
| OROS Research | 5 mg | — | — | 79 |
| Texpeptide | 10 mg | $50.00 | — | 70 |
| Crystal Peptides | 5 mg | $25.99 | — | 66 |
| Crystal Peptides | 10 mg | $44.99 | — | 66 |
| Qing Li Peptide | — | — | — | 63 |
| Certified Peptides | 10 mg | $67.00 | — | 62 |
| Nox Amino | 10 mg | $69.00 | — | 55 |
| Peptiatlas | — | — | — | 51 |
| MEI-PEPETIDE | 2 mg | $21.00 | — | 48 |
| DongCheng Peptide | — | — | — | 46 |
| Mandy | 5 mg | $28.00 | — | 43 |
| HongDa Peptide | — | $43.00 | — | 43 |
| zztai Peptide Ltd | — | — | — | 43 |
| MJT peptides | 5 mg | $38.00 | — | 39 |
| HK Peptide Ltd (hk peptides) | — | — | — | 37 |
| Alpha Peptides | — | — | — | — |
| Cernum Biosciences | 5 mg | $49.99 | — | — |
| Cernum Biosciences | 10 mg | $64.99 | — | — |
| NG Peptide | 10 mg | $42.00 | — | — |
| Strate Labs | 10 mg | $89.95 | — | — |
| AMC Essentials | 10 mg | $34.99 | — | — |
| AMC Essentials | 5 mg | $34.99 | — | — |
| Alpha Omega | 10 mg | $65.00 | — | — |
| Alpha Omega | 5 mg | $65.00 | — | — |
| Arcane Peptides | 5 mg | $30.00 | — | — |
| Atomik Labz | 10 mg | $56.00 | — | — |
| Biotech Peptides | 5 mg | $46.00 | — | — |
| Bulk Peptides | 5 mg | $160.00 | — | — |
| Core Peptides | 5 mg | $43.00 | — | — |
| Felix Chemical Supply | 5 mg | $29.99 | — | — |
| Felix Chemical Supply | 10 mg | $49.99 | — | — |
| Flawless Compounds | — | — | — | — |
| Genetic Peptide | 2 mg | $30.00 | — | — |
| Genetic Peptide | 5 mg | $30.00 | — | — |
| Genetic Peptide | 10 mg | $30.00 | — | — |
| Ignite Peptides | 10 mg | $50.00 | — | — |
| Kimera Chems | — | $31.99 | — | — |
| Modern Research Peptides | — | $26.99 | — | — |
| Nextech Labs | 10 mg | $56.00 | — | — |
| Oasis Labs | 5 mg | $34.50 | — | — |
| Oneday Compounds | 10 mg | $54.99 | — | — |
| Paramount Peptides | 10 mg | $80.00 | — | — |
| Peptide Crafters | 10 mg | $50.00 | — | — |
| Peptira | — | $69.00 | — | — |
| Pepvida Labs | 10 mg | $56.00 | — | — |
| Platinum Lion | 10 mg | $49.99 | — | — |
| Platinum Lion | 5 mg | $49.99 | — | — |
| Platinum Lion | — | $44.99 | — | — |
| Polaris Peptides | 10 mg | $50.00 | — | — |
| Puratek Peptides | 10 mg | $37.95 | — | — |
| Solution Peptides | 10 mg | $56.00 | — | — |
| Solution Peptides | 5 mg | $29.00 | — | — |
| Soma Peptides | 5 mg | $45.00 | — | — |
| Southern Aminos | 10 mg | $36.75 | — | — |
| True Peptide | 10 mg | $50.00 | — | — |
| True Peptide | 5 mg | $60.00 | — | — |
| Welli Labs | — | $47.99 | — | — |
| Wellness Peptides | — | $50.00 | — | — |
Research
Growth hormone-releasing peptides (GHRPs) comprise a group of small synthetic peptides that can effectively influence growth hormone secretion both in humans and animals.
source →Background Peptide therapeutics represent an emerging frontier in gerontological medicine, targeting fundamental hallmarks of aging including metabolic dysfunction, telomere attrition, tissue repair impairment, and hormonal decline.
source →Performance-enhancing drugs (PEDs) marketed as "research compounds" include unregulated peptides intended to modulate the growth hormone-insulin-like growth factor-1 (GH-IGF-1) axis.
source →Peptides are short chains of amino acids with a unique pharmacological niche between small-molecule drugs and large proteins. Their use in sports medicine is rapidly expanding, driven by patient demand for accelerated injury recovery and performance enhancement.
source →Background Therapeutic peptides are short-chain amino acids that regulate cellular functions and facilitate biochemical processes. In recent years, there has been significant growth in the global market for therapeutic peptides and thus its popularity among patients.
source →Background Injectable peptides are increasingly promoted for musculoskeletal recovery, tissue repair, and performance enhancements; however, clinical adoption has outpaced high-quality evidence and regulatory consensus.
source →Therapeutic peptides are short chains of amino acids used to treat metabolic and endocrine conditions such as obesity and type 2 diabetes.
source →The pursuit of pharmacological enhancement in sport has evolved from the widespread use of anabolic-androgenic steroids (AAS) to novel agents such as peptides and peptide analogues.
source →Therapeutic peptides are emerging as promising adjuncts in the management of orthopaedic injuries, grounded in their ability to modulate molecular signaling networks central to cellular medicine.
source →This study investigated whether ghrelin mimetics, namely anamorelin and ipamorelin, can alleviate weight loss and inhibition of feeding observed during acute and delayed phases of cisplatin-induced emesis in ferrets.
source →Ghrelin, a peptide found in the brain and gut, is predicted to play a significant role in the control of various physiological systems in fish. The objective of this study was to examine the impact of ipamorelin acetate (IPA), a ghrelin agonist, on the reproductive axis of the tilapia Oreochromis mossambicus.
source →Post-operative administration of ipamorelin is expected to reduce time to recovery of Gastrointestinal (GI) function in patients who have undergone partial small and/or large bowel resection.
source →The purpose of this study is to determine if ipamorelin is safe and effective in the management of post-operative ileus.
source →Human pharmacokinetic/pharmacodynamic study of ipamorelin (a GH secretagogue) in volunteers. Human data are limited to pharmacology; no clinical-outcome trials.
source →Ipamorelin induced longitudinal bone growth in rats — preclinical.
source →Foundational preclinical characterization of ipamorelin as the first selective growth-hormone secretagogue (animal models).
source →