TB-500
aka Thymosin Beta-4 fragment · TB4 fragment
Mechanism
Synthetic fragment of Thymosin Beta-4 active site. Studied for actin sequestration, cell migration, and tissue repair.
Studied uses
- soft tissue injury recovery (research only)
- wound healing studies
Identification
| CAS number | 885340-08-9 |
|---|---|
| Molecular formula | C38H68N10O14 |
| Sequence | LKKTETQ |
| Typical dose | 2–5 mg subcutaneous or intramuscular, 1–2x per week; loading phase typically 4–6 weeks |
| Half-life | ~1–2 hours (plasma; based on equine and in vitro studies) |
Safety
WADA-prohibited (S2 class). Not FDA-approved for human therapeutic use.
Vendors selling TB-500
| Vendor | Size | Price | Listed purity | Trust |
|---|---|---|---|---|
| Peptide Partners | 20 mg | $130.00 | — | 99 |
| Glacier Aminos | 10 mg | $58.99 | — | 99 |
| Moglabs | 5 mg | $36.00 | — | 96 |
| BioLongevity Labs | 10 mg | $164.97 | — | 96 |
| Orbitrex Peptides | 10 mg | $59.99 | — | 95 |
| Profound Aminos | 5 mg | $35.00 | — | 95 |
| Licensed Peptides | 10 mg | $584.95 | — | 95 |
| Licensed Peptides | 10 mg | $99.99 | — | 95 |
| Prime Peptides | 10 mg | $75.00 | — | 95 |
| Peptide Tech | — | $33.99 | — | 94 |
| Mile High Compounds | — | $59.99 | — | 94 |
| Forge Performance Co. | 10 mg | $60.00 | — | 94 |
| Amino Club | 10 mg | $39.99 | — | 93 |
| Riptide Wellness | — | $58.99 | — | 92 |
| Hydro Research Peptides | 10 mg | $0.65 | — | 91 |
| Skye Peptides | — | $69.00 | — | 90 |
| Peptidology | 10 mg | $56.99 | — | 89 |
| Peptide Plugs | 10 mg | $50.00 | — | 89 |
| Qihang Peptide | — | — | — | 87 |
| Verified Peptides | 10 mg | $62.00 | — | 86 |
| EZ Peptides | 10 mg | $48.00 | — | 85 |
| Simple Peptide | 10 mg | $65.00 | — | 85 |
| Simple Peptide | 15 mg | $65.00 | — | 85 |
| Peptidegurus | 10 mg | — | — | 84 |
| Peptidegurus | 2 mg | — | — | 84 |
| Peptidegurus | 5 mg | — | — | 84 |
| Peptidegurus | 10 mg | — | — | 84 |
| Ascension Peptides | 5 mg | $54.00 | — | 84 |
| Reta Peptide | — | — | — | 83 |
| Cocer Peptides | 10 mg | $180.00 | — | 82 |
| Cocer Peptides | 20 mg | $320.00 | — | 82 |
| Blank Peptides | 10 mg | $60.00 | — | 81 |
| OROS Research | 5 mg | — | — | 79 |
| OROS Research | 10 mg | — | — | 79 |
| Texpeptide | 10 mg | $60.00 | — | 70 |
| Crystal Peptides | 5 mg | $34.99 | — | 66 |
| Crystal Peptides | 10 mg | $59.99 | — | 66 |
| Qing Li Peptide | — | — | — | 63 |
| Certified Peptides | 10 mg | $70.00 | — | 62 |
| Peptiatlas | — | — | — | 51 |
| Taishijie | — | — | — | 51 |
| Taikangbio | — | — | — | 50 |
| Zjpeptix | — | — | — | 50 |
| MEI-PEPETIDE | 5 mg | $72.00 | — | 48 |
| Mandy | 5 mg | $66.00 | — | 43 |
| MJT peptides | 2 mg | $46.00 | — | 39 |
| HK Peptide Ltd (hk peptides) | 10 mg | $145.00 | — | 37 |
| Alpha Peptides | — | — | — | — |
| Apollo Peptide Sciences | 10 mg | $59.99 | — | — |
| Cernum Biosciences | 5 mg | $79.99 | — | — |
| Cernum Biosciences | 10 mg | $129.99 | — | — |
| NG Peptide | 10 mg | $35.00 | — | — |
| Ruo Bio | 5 mg | $36.00 | — | — |
| AMC Essentials | 10 mg | $64.99 | — | — |
| Alpha Omega | 10 mg | $65.00 | — | — |
| Alpha Omega | 15 mg | $65.00 | — | — |
| Amino Sequence | 10 mg | $65.00 | — | — |
| Arcane Peptides | 5 mg | $45.00 | — | — |
| Atomik Labz | 20 mg | $140.00 | — | — |
| Atomik Labz | 10 mg | $65.00 | — | — |
| Biotech Peptides | 5 mg | $72.00 | — | — |
| Biotech Peptides | 10 mg | $124.00 | — | — |
| Bulk Peptides | 10 mg | $280.00 | — | — |
| Bulk Peptides | 5 mg | $200.00 | — | — |
| Core Peptides | 5 mg | $78.00 | — | — |
| Core Peptides | 10 mg | $78.00 | — | — |
| Felix Chemical Supply | 10 mg | $69.99 | — | — |
| Flawless Compounds | — | — | — | — |
| Flawless Compounds | 30 mg | — | — | — |
| Genetic Peptide | — | $99.00 | — | — |
| Genetic Peptide | — | $125.00 | — | — |
| Genetic Peptide | 2 mg | $42.00 | — | — |
| Genetic Peptide | 5 mg | $42.00 | — | — |
| Genetic Peptide | 10 mg | $42.00 | — | — |
| Ignite Peptides | 5 mg | $40.00 | — | — |
| Ignite Peptides | 10 mg | $65.00 | — | — |
| Kimera Chems | — | $41.99 | — | — |
| Lumi Peptides | — | $50.00 | — | — |
| Modern Research Peptides | 10 mg | $46.99 | — | — |
| Nextech Labs | 10 mg | $75.00 | — | — |
| Nova Peptides | 5 mg | $34.99 | — | — |
| Nova Peptides | 10 mg | $34.99 | — | — |
| Oasis Labs | 10 mg | $57.00 | — | — |
| Oneday Compounds | 10 mg | $64.99 | — | — |
| Oneday Compounds | 20 mg | $89.99 | — | — |
| Oneday Compounds | 10 mg | $49.99 | — | — |
| Peptide Crafters | 10 mg | $65.00 | — | — |
| Peptira | — | $49.00 | — | — |
| Pepvida Labs | 20 mg | $130.00 | — | — |
| Pepvida Labs | 10 mg | $64.00 | — | — |
| Platinum Lion | 10 mg | $44.99 | — | — |
| Polaris Peptides | 10 mg | $110.00 | — | — |
| Polaris Peptides | 10 mg | $70.00 | — | — |
| Puratek Peptides | — | $59.95 | — | — |
| S1 Research | 10 mg | $40.00 | — | — |
| S1 Research | 10 mg | $66.00 | — | — |
| S1 Research | 10 mg | $50.00 | — | — |
| Solution Peptides | 20 mg | $140.00 | — | — |
| Solution Peptides | 10 mg | $65.00 | — | — |
| Southern Aminos | 10 mg | $51.75 | — | — |
| True Peptide | 10 mg | $45.00 | — | — |
| Welli Labs | — | $34.99 | — | — |
Research
Background Peptide therapeutics represent an emerging frontier in gerontological medicine, targeting fundamental hallmarks of aging including metabolic dysfunction, telomere attrition, tissue repair impairment, and hormonal decline.
source →Peptides are short chains of amino acids with a unique pharmacological niche between small-molecule drugs and large proteins. Their use in sports medicine is rapidly expanding, driven by patient demand for accelerated injury recovery and performance enhancement.
source →Background Therapeutic peptides are short-chain amino acids that regulate cellular functions and facilitate biochemical processes. In recent years, there has been significant growth in the global market for therapeutic peptides and thus its popularity among patients.
source →Therapeutic peptides are emerging as promising adjuncts in the management of orthopaedic injuries, grounded in their ability to modulate molecular signaling networks central to cellular medicine.
source →Therapeutic peptides are short chains of amino acids used to treat metabolic and endocrine conditions such as obesity and type 2 diabetes.
source →This fictional study is an example of a ClinicalTrials.gov-style record. It describes a Phase 1/2 trial evaluating the safety and tolerability of TB-500 (a 17-23 fragment of thymosin beta 4) versus placebo in adults with stable atherosclerotic cardiovascular disease (ASCVD).
source →Sodium butyrate and tributyrin are known to enhance broiler chicken performance.
source →Background TB-500 (Ac-LKKTETQ), derived from the active site of thymosin β4 (Tβ4), has various biological functions in its unacetylated form, LKKTETQ. These functions include actin binding, dermal wound healing, angiogenesis, and skin repair. The biological effects of TB-500, however, have not been documented.
source →Review of thymosin beta-4 in tissue repair and regeneration. Animal and mechanistic work; human efficacy remains unproven.
source →Boron nitride nanosheets (BNNSs) exfoliated from hexagonal boron nitride (h-BN) show great potential in polymer-based composites due to their excellent mechanical properties, highly thermal conductivity, and insulation properties.
source →The tendency of peptides to adsorb to surfaces can raise a concern in variety of analytical fields where the qualitative/quantitative measurement of low concentration analytes (ng/mL-pg/mL) is required.
source →Review of thymosin beta-4 (the basis of TB-500) as a multifunctional regenerative peptide. No human efficacy RCTs — evidence is preclinical and mechanistic.
source →A veterinary preparation known as TB-500 and containing a synthetic version of the naturally occurring peptide LKKTETQ has emerged. The peptide segment (17)LKKTETQ(23) is the active site within the protein thymosin β(4) responsible for actin binding, cell migration and wound healing.
source →The formulation TB-500 is suspected to be used as doping agent in sport.
source →