MOTS-c
aka Mitochondrial Open reading frame of the Twelve S rRNA type-c
Mechanism
MOTS-c is an investigational mitochondrial-derived peptide studied preclinically for metabolic regulation. It is research-only and not FDA-approved; the CB4211 analog program (CohBar) was discontinued in 2023.
Identification
| CAS number | 1627580-64-6 |
|---|---|
| Molecular formula | C101H152N28O22S2 |
| Sequence | MRWQEMGYIFYPRKLR |
| Typical dose | 5–10 mg subcutaneous, 2–3 times per week (research use) |
| Half-life | ~4–6 hours (estimated; exercise-induced endogenous levels return to baseline within ~4 hours) |
Vendors selling MOTS-c
| Vendor | Size | Price | Listed purity | Trust |
|---|---|---|---|---|
| Peptide Partners | 20 mg | $91.00 | — | 99 |
| Peptide Partners | 80 mg | $252.00 | — | 99 |
| Glacier Aminos | 10 mg | $45.99 | — | 99 |
| Glacier Aminos | 20 mg | $45.99 | — | 99 |
| Moglabs | 10 mg | $38.00 | — | 96 |
| BioLongevity Labs | 10 mg | $109.97 | — | 96 |
| Crush Research | 10 mg | — | — | 95 |
| Crush Research | 20 mg | — | — | 95 |
| Crush Research | 40 mg | — | — | 95 |
| Orbitrex Peptides | 10 mg | $49.99 | — | 95 |
| Profound Aminos | 10 mg | $69.00 | — | 95 |
| Ion Peptide | — | $42.00 | — | 95 |
| Reta One Labs | 40 mg | $72.00 | — | 95 |
| Reta One Labs | 10 mg | $29.00 | — | 95 |
| Licensed Peptides | 10 mg | $449.96 | — | 95 |
| Licensed Peptides | 10 mg | $76.99 | — | 95 |
| Licensed Peptides | 40 mg | $76.99 | — | 95 |
| Prime Peptides | 10 mg | $55.00 | — | 95 |
| Peptide Tech | 10 mg | $43.99 | — | 94 |
| Mile High Compounds | 10 mg | $49.99 | — | 94 |
| Mile High Compounds | 40 mg | $49.99 | — | 94 |
| Forge Performance Co. | 20 mg | $60.00 | — | 94 |
| Amino Club | — | $39.99 | — | 93 |
| Riptide Wellness | — | $127.99 | — | 92 |
| Hydro Research Peptides | 10 mg | $0.35 | — | 91 |
| Skye Peptides | 10 mg | $54.00 | — | 90 |
| Peptidology | 10 mg | $49.00 | — | 89 |
| Peptidology | 40 mg | $49.00 | — | 89 |
| Peptide Plugs | 10 mg | $30.00 | — | 89 |
| Peptide Plugs | 40 mg | $100.00 | — | 89 |
| Qihang Peptide | — | — | — | 87 |
| Verified Peptides | — | $43.00 | — | 86 |
| EZ Peptides | 10 mg | $54.00 | — | 85 |
| Simple Peptide | — | $149.00 | — | 85 |
| Simple Peptide | — | $43.00 | — | 85 |
| Peptidegurus | 5 mg | — | — | 84 |
| Peptidegurus | 10 mg | — | — | 84 |
| Ascension Peptides | 10 mg | $49.00 | — | 84 |
| Reta Peptide | — | — | — | 83 |
| Cocer Peptides | 10 mg | $88.00 | — | 82 |
| MedGe Peptides | 10 mg | $65.00 | — | 82 |
| Blank Peptides | 10 mg | $55.00 | — | 81 |
| OROS Research | 10 mg | — | — | 79 |
| OROS Research | 20 mg | — | — | 79 |
| Texpeptide | 10 mg | $45.00 | — | 70 |
| Crystal Peptides | 10 mg | $44.99 | — | 66 |
| Qing Li Peptide | — | — | — | 63 |
| Qing Li Peptide | 10 mg | — | — | 63 |
| Certified Peptides | 40 mg | $160.00 | — | 62 |
| Certified Peptides | 20 mg | $90.00 | — | 62 |
| Certified Peptides | 10 mg | $58.00 | — | 62 |
| Nox Amino | 10 mg | $59.00 | — | 55 |
| Peptiatlas | — | — | — | 51 |
| Taishijie | — | — | — | 51 |
| Taikangbio | — | — | — | 50 |
| MEI-PEPETIDE | 10 mg | $60.00 | — | 48 |
| DongCheng Peptide | — | — | — | 46 |
| Mandy | 10 mg | $49.00 | — | 43 |
| HongDa Peptide | — | $71.00 | — | 43 |
| zztai Peptide Ltd | — | — | — | 43 |
| MJT peptides | 10 mg | $68.00 | — | 39 |
| Alpha Peptides | — | — | — | — |
| Cernum Biosciences | 10 mg | $69.99 | — | — |
| NG Peptide | 40 mg | $80.00 | — | — |
| Ruo Bio | 10 mg | $36.00 | — | — |
| AMC Essentials | 40 mg | $89.99 | — | — |
| Alpha Omega | — | $149.00 | — | — |
| Alpha Omega | — | $43.00 | — | — |
| Amino Sequence | 40 mg | $95.00 | — | — |
| Arcane Peptides | 10 mg | $45.00 | — | — |
| Atomik Labz | 40 mg | $99.00 | — | — |
| Atomik Labz | 10 mg | $39.00 | — | — |
| Biotech Peptides | 10 mg | $99.00 | — | — |
| Bulk Peptides | 10 mg | $180.00 | — | — |
| Core Peptides | 10 mg | $116.00 | — | — |
| Felix Chemical Supply | 10 mg | $59.99 | — | — |
| Flawless Compounds | — | — | — | — |
| Genetic Peptide | 10 mg | $110.00 | — | — |
| Genetic Peptide | 20 mg | $110.00 | — | — |
| Genetic Peptide | 60 mg | $110.00 | — | — |
| Ignite Peptides | 10 mg | $48.00 | — | — |
| Kimera Chems | 10 mg | $51.99 | — | — |
| Lumi Peptides | — | $70.00 | — | — |
| Lumi Peptides | — | $40.00 | — | — |
| Modern Research Peptides | — | $34.99 | — | — |
| Nextech Labs | 10 mg | $99.99 | — | — |
| Nova Peptides | 10 mg | $49.99 | — | — |
| Nova Peptides | 40 mg | $49.99 | — | — |
| Oasis Labs | 10 mg | $48.50 | — | — |
| Oasis Labs | 40 mg | $48.50 | — | — |
| Oneday Compounds | 10 mg | $54.99 | — | — |
| Paramount Peptides | 10 mg | $65.00 | — | — |
| Peptide Crafters | 15 mg | $55.00 | — | — |
| Peptide Crafters | 10 mg | $30.00 | — | — |
| Peptira | 40 mg | $139.00 | — | — |
| Peptira | 10 mg | $49.00 | — | — |
| Pepvida Labs | 10 mg | $49.00 | — | — |
| Platinum Lion | — | $114.99 | — | — |
| Polaris Peptides | 10 mg | $55.00 | — | — |
| Puratek Peptides | 10 mg | $29.95 | — | — |
| Puratek Peptides | 40 mg | $29.95 | — | — |
| S1 Research | 40 mg | $45.00 | — | — |
| S1 Research | 10 mg | $45.00 | — | — |
| Solution Peptides | 40 mg | $99.00 | — | — |
| Solution Peptides | 10 mg | $39.00 | — | — |
| Soma Peptides | 10 mg | $79.00 | — | — |
| Southern Aminos | 10 mg | $30.94 | — | — |
| Southern Aminos | 40 mg | $30.94 | — | — |
| True Peptide | 40 mg | $108.00 | — | — |
| True Peptide | 10 mg | $36.00 | — | — |
| Welli Labs | — | $29.99 | — | — |
| Welli Labs | — | $52.99 | — | — |
Research
This study investigates how different types of fasting affect cell health, specifically focusing on how mitochondria (the energy-producing parts of cells) are cleared and renewed.
source →Objective MOTS-c is a mitochondria-derived peptide associated with reduced insulin resistance and obesity. The m.1382A>C polymorphism of the MOTS-c gene is linked to an increased risk of type 2 diabetes in men.
source →Background Cancer cachexia is a multifactorial metabolic syndrome marked by progressive skeletal muscle loss, reduced function, and increased mortality. Mitochondrial dysfunction is a key driver of this phenotype.
source →Background: Atrial fibrillation (AF) is a common clinical arrhythmia associated with mitochondrial dysfunction, oxidative stress, and atrial fibrosis. Mitochondrial-derived peptides (MDPs), including humanin (HN) and MOTS-c, exhibit cytoprotective properties, but their role in AF remains largely unknown.
source →Type 2 diabetes mellitus (T2DM) is associated with chronic systemic and cardiac inflammation, contributing to the development of diabetic cardiomyopathy.
source →Background MOTS-c is a mitochondrial-derived microprotein (mitokine) encoded within the 12 S rRNA gene that exerts intracrine, paracrine, and endocrine effects across multiple tissues.
source →Purpose Oxidative stress (OS) and endothelial dysfunction are major drivers of cardiovascular disease (CVD) in peritoneal dialysis (PD).
source →Introduction Mitochondrial open reading frame of the 12S rRNA type-c (MOTS-c), a 16-amino acid mitochondrial-derived peptide, regulates cellular metabolism through AMPK and mTOR signaling and exerts protective effects across multiple endocrine tissues. However, its role in adrenal physiology remains unexplored.
source →Background Mitochondrial dysfunction contributes substantially to myocardial ischemia-reperfusion (IR) injury through impaired bioenergetics, oxidative stress, and disruption of mitochondrial homeostasis.
source →Background : Hashimoto's thyroiditis (HT) is a common autoimmune disorder characterized by chronic inflammation and metabolic alterations.
source →Mitochondrial function is critical for spermatogenesis and male fertility. MOTS-c, a mitochondrially encoded regulatory peptide, has recently been reported to effectively protect testicular spermatogenesis in mice, but its specific role and mechanism remain unclear.
source →Distal ischemic necrosis remains a major challenge in reconstructive surgery. Mitochondria and lysosomes interact via signaling and membrane contacts to maintain cellular homeostasis.
source →Renal transplantation is the most effective renal replacement therapy for patients with end-stage renal disease. Ischemia-reperfusion injury may adversely affect graft function and long-term outcomes.
source →This Phase 2a study evaluates whether 12 weeks of treatment with investigational MOTS-c improves insulin sensitivity compared with placebo in adults with prediabetes and overweight/obesity.
source →This study aims to analyze the effects of physical activity in patients with chronic kidney disease undergoing dialysis or conservative treatment. Patients will be randomized into two groups: combined exercise (high-intensity aerobic resistance + strength training) and control group
source →MOTS-c reduced myostatin and muscle-atrophy signaling in preclinical models.
source →The investigators are doing this study to determine if there are body composition changes after a 12-week exercise program in breast cancer patients and determine what factors contribute to sustained physical activity after the 12-week exercise program intervention.
source →A.
source →Review of MOTS-c as a mitochondrial-derived peptide regulating muscle and fat metabolism. Preclinical.
source →This study was based on a concurrent newborn genetic and hearing screening program in Nantong city. From January 2016 to December 2020, newborn infants were recruited and received combined screening for free, funded in part by the municipal government and research project foundations.
source →Foundational study: the mitochondrial-derived peptide MOTS-c improved metabolic homeostasis and reduced obesity and insulin resistance in mice. Preclinical.
source →Increased circulating b-amyloid and decreased Mitochondrial-derived peptide (MOTS-c), a peptide improving tissue insulin sensitivity, are reported in diabetes.
source →